Synthesis and investigation of the trypanocidal potential of novel 1,2,3-triazole-selenide hybrids

Synthesis and evaluation of photophysical, electrochemical, and ROS generation properties of new chalcogen-naphthoquinones-1,2,3-triazole hybrids

“…6, we can observe the comparison and relationship of potentials and energies for derivatives with different chalcogens ( 11a , 11i , and 11j ). Derivatives containing S and Se atoms ( 11a and 11i ) were similar in terms of redox potentials, 43 with only the Te derivative ( 11j ) having atypical values of redox potentials. This fact can be attributed to a change in the electronic conjugation of the molecule, disfavoring oxidation processes, making it more difficult to form a radical cation species in solution.…”

Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models

“…The new 1,2,3-triazole-2-nitroimidazole series also revealed high potency against T. cruzi in vitro , with 5-fold more activity than Bz [ 23 ]. Recently, new 1,2,3-triazole-selenide hybrids also showed anti- T. cruzi activity comparable to the reference drug [ 47 ]. Our data highlight the potential of 1-(4-diphenyl)-1 H -1,2,3-triazole derivatives against T. cruzi , with a nanomolar activity for trypomastigotes (100-fold more active than Bz) and similar potency to Bz for intracellular parasites.…”

Ecofriendly aminochalcogenation of alkenes: a green alternative to obtain compounds with potential anti-SARS-CoV-2 activity

“…1,9 On the other hand, among the most studied heterocyclic systems are triazoles, which have attracted the interest of researchers due to their wide range of applications, which include explosives, agrochemicals, and drugs. 10,11 At the basis of these features is the benzotriazole nucleus, which is formed by the fusion of a benzene with a triazole ring. In particular, this heterocycle is a component of a wide range of compounds with diverse biological activities.…”