Synthesis and Insecticidal Activity Study of Azidopyridryl Containing Dichlorolpropene Ether Derivatives

Abstract

Pyridalyl, as a novel insecticide with an unknown mode of action, has shown excellent control efficacy against lepidopterous larvae and thrips. Previous modifications of this compound have mostly focused on the pyridine moiety, with limited information available about modifications to other parts of pyridalyl. In this paper, we report the synthesis and insecticidal activity of a series of azidopyridryl-containing dichlorolpropene ether derivatives, based on modifications to the middle alkyl chain of pyridalyl. Screening results for insecticidal activity indicate that our synthesized compounds show moderate to high activities at the tested concentrations against P. xylostella. Particularly, compound III-10 exhibits a LC 50 value of 0.831 mg L −1 , compared to the LC 50 value of pyridalyl at 2.021 mg L −1 . Furthermore, compound III-10 also displays a relatively broad insecticidal spectrum against Lepidoptera pests M. separata, C. suppressalis, O. nubilalis, and C. medinalis. Finally, in field trials, III-10 demonstrates better control efficiency against Chilo suppressalis compared to pyridalyl. Overall, our findings suggest that the modification of the middle alkyl chain of pyridalyl may be a promising approach for developing insecticides with improved efficacy.

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

“…Studies show that 2-pyrazolines have a vital function in organic and biological chemistry [13][14][15][16], as well as being effective insecticides [17][18][19][20]. Furthermore, the pyridine ring appears in a wide range of synthetic chemistry [21,22], including agrochemicals and insecticides [23][24][25][26][27][28]. As a result of the aforementioned and continuing teamwork [29][30][31][32][33][34][35][36], we are interested in developing novel 2-pyrazoline or pyridine analogs combining pyrazolopyridine and pyrazole nuclei having molluscicidal activity against the land snail, T. pisana.…”