Synthesis and insecticidal activity of novel 1,2,4‐triazole containing amidine moiety

Zhao, Fenghai; Liu, Yanfei; Qin, Zhaohai; Wu, Yanhua; Xiao, Yumei; Li, Jiaqi

doi:10.1002/jhet.4500

Cited by 6 publications

(2 citation statements)

References 26 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds containing nitrogen in their structure are used widely as pharmaceuticals and agrochemicals; and show promising biological activity. They have a variety of applications as in herbicides [1], insecticides [2], photo-polymericadhesives [3], flavor and fragrances [4], pesticides [5], dyes [6] and drugs [7]. Nitrogenous compounds are of huge interest to the researchers around the world due to their vast area of the biological activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles

Aryal

Shakya

2023

J. Nepal Chem. Soc.

View full text Add to dashboard Cite

The development of a potent new drug with high biological activity is a challenge in drug design and is of strategic importance. Due to the increasing resistance of pathogens on the available drugs, there is always a demand for designing a potent drug with high biological activity. The pharmacological effects have been observed in compounds containing different moieties of pharmaceutical importance such as triazole, Schiff’s base, benzimidazole.Triazole thione, Schiff’s bases, and two new compounds containing three pharmacophores viz. triazole, benzimidazole, and Schiff base incorporated in a single compound were prepared by applying different synthetic reactions. Different spectroscopic methods, including FT-IR, UV-vis, 1H-NMR, and 13C-NMR, were used to confirm the structure of the prepared compounds. All compounds exhibited moderate antibacterial activity against Staphylococcus aureus (ATCC 6538P) and Staphylococcus epidermidis (ATCC 1228). Antioxidant activity was carried out by DPPH radical scavenging test and among the tested five compounds, the IC50 value of 4-amino-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5(4H)-thione was found to be 32.364 μg.mL-1 which is closer to the ascorbic acid that was found to be 28.546 μgmL-1. All tested compounds were toxic against brine shrimp where 2-(5-((1H-benzo[d]imidazol-2-yl)thio)-4-((4-chlorobenzylidene) amino)-4H-1,2,4-triazol-3-yl) was comparatively more toxic (LC50= 26.827 μgmL-1).

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles

Aryal

Shakya

2023

J. Nepal Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…Some fused pyrazole derivatives have also demonstrated different photophysical and exceptional biological activities and showed great synthetic versatility of crucial chemicals products in the industrial and pharmaceutical field [1]. We can quote the amidine which is a dual nucleophile due to the presence of two nitrogen atoms [2] and was known as a perfect precursors for the synthesis of a wide variety of pharmaceuticals and biologically active heterocyclic systems [2][3][4]. Indeed, they have some interesting therapeutic properties such as anti-inflammatory [5,6], antimicrobial [7], antiparasitic [8], antibacterial [9,10], anticancer [11,12], antiprotozoal [13], antifungal [14], antidepressant [15,16], anti-Parkinson [17] and antitumor activities [18].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity, Dielectric and Electrical Properties of N-benzyl-N'-(5-methyl-1H-pyrazol-3-yl) propanimidamide.

Louiz,

Labiadh,

Abderrahim

et al. 2023

Preprint

View full text Add to dashboard Cite

This article mainly focuses on recent advances in the study of the interesting electronic and biological powers of the N-benzyl-N'-(5-methyl-1H-pyrazol-3-yl) propanimidamide. The selected amidine has been previously synthesized, characterized in a previous publication and we present in this research the study of the antioxidant application, electrical activity and dielectric studies of the cristal. In this context, the amidine and the corresponding imidate were compared with ascorbic acid as a reference and showed an interesting antioxidant power, especially in Ferrous ion chelating (FIC) activity and Hydroxyl Radical (OH.) Scavenging. We also studied electrical activity as a function of frequency, impedance and alternating conductivity. The obtained results showed that the compound can be used in order to complex and impedance spectroscopy showed that synthesized amidine is a good short-range proton conductor. Impedance measurements approve the input of the resistive grain frontier on the conduction mechanism. Then, it evidences the existence of many electrical relaxation phenomena in the studied sample. The dielectric constant is temperature dependent indicating that the crystal is a polar dielectric compound and the dipole orientation is governed by increasing temperature.

show abstract

Research progress of triazole derivatives in the discovery of agricultural chemicals

Song,

Wang,

Cai

et al. 2023

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

Triazole groups play an important role in the construction of agricultural bioactive molecules, often acting as linking units to organically graft different pharmacophore groups, so as to obtain efficient and broad‐spectrum pesticide molecules. After decades of development, triazole derivatives have made remarkable achievements in the discovery of pesticides, especially the discovery of fungicides. In addition, highly effective triazole insecticides, herbicides, and anti‐plant virus agents have also been found, and commercial triazole pesticides have occupied a large market share. At present, the study of triazole compounds has become one of the important fields in the development of new pesticides. We systematically reviewed the application of triazole derivatives in the discovery of new pesticides since 2010, summarized the antifungal, antibacterial, insecticidal, herbicidal, and anti‐plant virus activities of triazole derivatives, and discussed the structure–activity relationship and mechanism of action in order to provide inspiration and ideas for the discovery of new triazole agrochemicals.

show abstract

Synthesis and insecticidal activity of novel 1,2,4‐triazole containing amidine moiety

Cited by 6 publications

References 26 publications

Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles

Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles

Antioxidant activity, Dielectric and Electrical Properties of N-benzyl-N'-(5-methyl-1H-pyrazol-3-yl) propanimidamide.

Research progress of triazole derivatives in the discovery of agricultural chemicals

Contact Info

Product

Resources

About