Synthesis and Insecticidal Activity of Some 1,3,4‐Oxadiazole Derivatives Containing Phenoxyfluorophenyl Group.

Mohan, T. P.; Vishalakshi, B.; Bhat, K. Subrahmanya; Rao, K. Srinivasa; Kendappa, G. N.

doi:10.1002/chin.200450091

Cited by 20 publications

(23 citation statements)

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“…1,3,4-Oxadiazole was found to possess a wide spectrum of pharmacological activity such as antibacterial [3][4] , anti fungal [5][6] , anthelminitic 7 , anti tubercular 8 , anti-infective 9 , anti cancer 10 , anti-HIV 11 , anti oxidant 12 , analgesic [13][14] , anti histanamic 15 , insectivdal 16 , anti-inflammatory 17 , and anti convulsant [18][19] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

2017

Chem Sci Trans

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New derivatives of 1,3,4-oxadiazole, synthesized by the condensation of different substituted benzoic acids with 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl) acetohydrazide using SOCl 2 as well as POCl 3 as cyclization reagents. Ethyl-2-(1-phenyl-1,2,3,4-tetrahydroisoquinoline)-ethaonate was synthesized from 1,2,3,4-Tetrahydroisoquinoline and it was converted to the 2-(1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl)acetohydrazide. This compound is the key intermediate for the 1,3,4-oxadiazole compounds. All the synthesized molecules were characterized by advanced spectral data and also studied their biological activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

2017

Chem Sci Trans

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“…The molecules bearing heterocyclic 1,3,4-Oxadiazole ring [1][2][3][4] , acetamoyl moiety [5][6][7][8][9] and azomethine moiety [10][11][12][13] have been demonstrated to exhibit a wide spectrum of pharmacological activities including anticancer, antimicrobial, antidepressant, anti-inflammatory, antioxidant, anticonvulsant and many other activities. We have introduced different molecules possessing multiple functionalities [14][15][16][17] along with remarkable antibacterial and antienzymatic activities.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Enzyme Inhibition Screening of Some New Acetamide and Azomethine Derivatives

Rasool

Aziz-Ur-Rehman

Abbasi

et al. 2015

J. Chil. Chem. Soc.

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The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with different electrophiles, prepared by the reaction of aryl/alkyl amines with 2-bromoacetylbromide, in NaH/DMF to synthesize N-substituted-2-( (5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. The molecule 4 was stepped to ethyl ester and carbohydrazide. The carbohydrazide was made to react with aryl carboxaldehydes in methanol to synthesize N 3,acetohydrazide, 11a-i. The structures of all the molecules were corroborated through IR, 1 H-NMR and EI-MS spectral data. Both the series were screened for antibacterial and enzyme inhibition activity.

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“…They have also been used in pesticide chemistry, 6 polymer 7 and material science. [8][9][10] 1,3,4-Oxadiazoles have been synthesized by traditional methodology via several approaches, three of the more popular being the cyclization of diacylhydrazines, 11 the cyclization of acylthiosemicarbazides, 12 and the oxidation of acylhydrozones.…”

Section: Introductionmentioning

confidence: 99%

Silica-supported dichlorophosphate: a recoverable cyclodehydrant for the eco-friendly synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under solvent-free and microwave irradiation conditions

Zheng¹,

Zhu²,

Xue-rong³

et al. 2008

J. Braz. Chem. Soc.

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Uma série de compostos simétricos e assimétricos de 2,5-dissubstituídos 1,3,4-oxadiazol foram sintetizados eficientemente a partir do ciclodesidratação das diacilhidrazinas, usando a sílica suportada com o diclorofosfato, como recuperador do ciclodesidratação sem solvente e sob irradiação por microondas. Este processo tem vantagens de ser não corrosivo e nem poluente, apresenta ainda velocidade acelerada, alto rendimento e simples procedimento experimental.A series of symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclodehydration of diacylhydrazines by using silica-supported dichlorophosphate as a recoverable cyclodehydrant in solvent-free medium under microwave irradiation. This protocol has advantages of no corrosion, no environmental pollution, accelerated rate, high yield and simple work-up procedure.

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Synthesis and Insecticidal Activity of Some 1,3,4‐Oxadiazole Derivatives Containing Phenoxyfluorophenyl Group.

Cited by 20 publications

References 0 publications

Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

Synthesis and Characterization of 1,3,4-Oxadiazoles Derivatives from 1,2,3,4-Tetrahydroisoquinoline and their Bioevalution (Antibacterial & Antifungal)

Antibacterial and Enzyme Inhibition Screening of Some New Acetamide and Azomethine Derivatives

Silica-supported dichlorophosphate: a recoverable cyclodehydrant for the eco-friendly synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under solvent-free and microwave irradiation conditions

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