Synthesis and insecticidal activities of pyrethroids derived from 3-methyl-2-(3',4'-dihydronaphthyl)butanoic acids

A possible potential COVID-19 drug candidate: Diethyl 2-(2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetyl)hydrazono)malonate: Docking of disordered independent molecules of a novel crystal structure, HSA/DFT/XRD and cytotoxicity

“…Malonate-based compounds have aroused increasing attention because of their important pharmacological activities, such as decreased blood glucose ( Shinkai et al, 1998 ) anti-HIV ( Serafin et al, 2011 ) anticancer ( Xing et al, 2012 ) anti-inflammatory ( Kim et al, 2001 ) antioxidative ( Saranya et al, 2013 ) and antiviral ( Xiao et al, 2014 ) activities. Moreover, malonates are traditionally regarded as important materials for synthesizing the key intermediates of numerous active substances ( Wheeler, 1984 , Woo et al, 1989 , Ragoussis et al, 2004 , Brandau et al, 2006 ). The binding affinity and structure of protein-drug complexes play an important role in understanding the molecular mechanism in drug discovery.…”