Synthesis and inhibitory effects on platelet aggregation of 3-(2-thienyl)- and 3-(1-imidazolyl)-1,2-benzisoxazole derivatives

Synthesis and Study of Oxadisilole‐Fused Benzisoxazoles or Naphthisoxazoles

“…[3] Benzisoxazole derivatives are associated with various biological activities, such as antipsychotic, [4] antitumor, [5] anticonvulsant, [6] antimicrobial, [7] antithrombotic [8] and antidiabetic effects. [9] Aryne is an important intermediate and synthon in organic synthesis.…”

Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity

“…2 Among the various biologically active isoxazole derivatives, substituted 1,2-benzisoxazoles occupy an extremely important role in the pharmaceutical and medicinal fields. 3, 4 1,2-Benzisoxazoles substituted derivatives were used as anticonvulsant, 5,6 anti-psychotic, 7 anti-cancer, 8,9 antimicrobial, 10 anti-thrombotic, 11 uricosuric, 12 anti-inflammatory, 13 tuberculostatic, 14 sedative, 15 analgesic 16 and neuroleptic agents. 17 In addition, N-benzylpiperidinebenzisoxazole derivatives are selective inhibitors of the enzyme acetyl cholinesterase (AChE), used for the treatment of Alzheimer's disease.…”

Solution-Phase Synthesis of a Diverse Library of Benzisoxazoles Utilizing the [3 + 2] Cycloaddition of in Situ-Generated Nitrile Oxides and Arynes

“…1 Among them, the benzisoxazole scaffold has evolved as a convenient bioisosteric replacement for the benzoyl functionality of some biologically active molecules. 2 Benzisoxazoles, particularly their 3-alkyl and 3-aryl substituted derivatives, have displayed a broad range of biological activities, such as antipsychotic, 2a,3 antitumor, 4 anticonvulsant, 5 antimicrobial, 6 antibacterial, 7 diuretic, 8 antithrombotic, 2c and acetylcholinesterase-inhibition 2b,9 (Alzheimer’s disease treatment) activities (Figure 1). …”