Abstract:A series of N-(benzoylphenyl)-carboxamide derivatives (2a, 2b, 3a, 3b, 4a, 4b, 5a, 5b, 6a and 6b) was prepared with good yields by reacting the corresponding carbonyl chlorides with aminobenzophenones at room temperature. This was followed by evaluating the hypotriglyceridemic and hypocholesterolemic effects of 3b, 5a and 5b. Triton WR-1339 (300 mg/kg) was intraperitoneally administered to overnight-fasted rats to induce hyperlipidemia. Rats were divided into six groups: control, hyperlipidemic, hyperlipidemic… Show more
“…A model of acute hyperlipidemia was created in rats within 24 hours with Triton WR-1339, which we used in our current study. Our model was supported by using this induction in the study in which the anti-hyperlipidemic properties of Campomanesia xanthocarpa leaves (De Sousa et al, 2019) and N-(Benzoylphenyl)-Carboxamide derivatives were determined (Sweidan et al, 2022). With the application of Triton WR-1339 by Attia et al (2020), TGs, TC, LDL-C and lipid peroxidation (LPO) increased and HDL-C decreased (Attia et al, 2020).…”
Section: Lipid Peroxidation and Antioxidant System Modulation Of E-ws...mentioning
In the study, the seed coat (WSC) of Posof (Ardahan/Türkiye) walnuts was extracted to determine their phytochemical components and antioxidant capacities. The effects of bioactive components in the ethanol extract of WSC (E-WSC) on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors were investigated. Additionally, antioxidant enzyme activity parameters were measured in the kidney tissues of Triton WR-1339-induced hyperlipidemic rats. Bioactive compounds in WSC were identified by GC-MS system. The antioxidant properties of WSC were measured using Fe+3, Cu+2 and Fe+3-2,4,6-tripyridyl-s-triazine (TPTZ) reducing agent, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'- azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activities. In this analysis, using 30 male Wistar rats (300 ± 30 g) randomly divided into five groups were treated as follows; K1: Healthy control group, K2: E-WSC (150 mg) o.d., K3: E-WSC (300 mg) o.d., K4: Hyperlipidemic group i.p., K5: Hyperlipidemic group i.p. + E-WSC (300 mg) o.d. Superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) analyzes were performed in kidney tissues. Based on these results, it was clearly determined that E-WSC has significant antioxidant activity due to its bioactive components, has an inhibitory effect on AChE and BChE enzymes, and has a protective effect against oxidative stress by improving hyperlipidemia-related kidney damage.
“…A model of acute hyperlipidemia was created in rats within 24 hours with Triton WR-1339, which we used in our current study. Our model was supported by using this induction in the study in which the anti-hyperlipidemic properties of Campomanesia xanthocarpa leaves (De Sousa et al, 2019) and N-(Benzoylphenyl)-Carboxamide derivatives were determined (Sweidan et al, 2022). With the application of Triton WR-1339 by Attia et al (2020), TGs, TC, LDL-C and lipid peroxidation (LPO) increased and HDL-C decreased (Attia et al, 2020).…”
Section: Lipid Peroxidation and Antioxidant System Modulation Of E-ws...mentioning
In the study, the seed coat (WSC) of Posof (Ardahan/Türkiye) walnuts was extracted to determine their phytochemical components and antioxidant capacities. The effects of bioactive components in the ethanol extract of WSC (E-WSC) on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors were investigated. Additionally, antioxidant enzyme activity parameters were measured in the kidney tissues of Triton WR-1339-induced hyperlipidemic rats. Bioactive compounds in WSC were identified by GC-MS system. The antioxidant properties of WSC were measured using Fe+3, Cu+2 and Fe+3-2,4,6-tripyridyl-s-triazine (TPTZ) reducing agent, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'- azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activities. In this analysis, using 30 male Wistar rats (300 ± 30 g) randomly divided into five groups were treated as follows; K1: Healthy control group, K2: E-WSC (150 mg) o.d., K3: E-WSC (300 mg) o.d., K4: Hyperlipidemic group i.p., K5: Hyperlipidemic group i.p. + E-WSC (300 mg) o.d. Superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) analyzes were performed in kidney tissues. Based on these results, it was clearly determined that E-WSC has significant antioxidant activity due to its bioactive components, has an inhibitory effect on AChE and BChE enzymes, and has a protective effect against oxidative stress by improving hyperlipidemia-related kidney damage.
“…J., 2023: 372. doi: https://doi.org/10.54112/bcsrj.v2023i1.372] 2 common botanical name is Ficus carica (Wang et al, 2022).Figs are considered hypolipidemic agents (Siyadatpanah et al, 2022). The anti-dyslipidemic effects of Ficus Carica are due to phenolic compounds like chlorogenic and vanillic acids (Sweidan et al, 2022).These compounds act as antioxidant agents.…”
Dyslipidemia is one of the predisposing factors for the development of cardiovascular diseases due to the formation of atherosclerosis. Statin drugs are commonly used for the management of dyslipidemia but due to different side effects, drug resistance and affordability issues now, researchers working on the different preventive and curative effects of different natural herbs, fruits, etc. this study aimed to evaluate & compare the preventive effects of Ficus Carica & Allium Sativum on serum lipid profile levels in albino rats on induction of dyslipidemia. This experimental study was conducted at the Department of Biochemistry Liaquat University of Medical & Health Sciences (LUMHS) Jamshoro, Pakistan. Total of 24 male albino rats weighing of 170-190 grams were purchased from the Ojha campus of DUMHS Karachi Pakistan and caged at the Animal House of Agriculture University Tando Jam Pakistan. Twenty-four male albino rats were divided into four groups; each group contained 6 rats, group A as control group received a normal diet; group B rats received high fatty diet; group C rats received high fatty diet along with figs powder; group D rats received a high fatty diet with garlic powder with the calculated and proper dose for six weeks. After six weeks, orbital capillary blood samples were drawn to estimate lipid profile parameters. Lipid profile performed on Cobas chemical analyzer of Roche Hitachi at Diagnostic & Research Laboratory LUMHS. The Statistical data was analyzed by SPSS version 21 by applying ANOVA test for significance. The serum cholesterol level was highly observed in group B rats, and serum cholesterol level was significantly (P < .001) low in the group C & D rats in comparison to group B male albino rats. The serum T.G. level is highly observed in group B rats, T.G.’s level is significantly (P < .001) low in the group C & D rats compared to group B male albino rats. The serum LDL level is highly observed in group B rats, with a significant serum LDL level (P = 0.05) low in the group C & D rats compared to group B male albino rats. The serum HDL level more decline in group B rats serum HDL level was significantly (P = 0.05) high in the group C & D rats with the comparison to group B male albino rats. Figs and garlic powder had a significant role in normal levels of different lipid profile parameters. This study concluded that figs powder and garlic powder could perform a preventive role in the development of dyslipidemia.
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