Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents

Cytotoxicity, Cell Cycle Arrest, Antioxidant Activity and Interaction of Dibenzoxanthenes Derivatives with DNA

“…Additionally, they also show important biological activity. Some evidence suggests that the xanthene core structure also may be useful in the design and development of pharmacological agents (Chibale et al, 2003;Bhattacharya, et al, 2009). Naya studied the structureactivity relationships of a series of 2,9-disubstituted xanthenes as chemokine receptor (CCR1) antagonists (Naya et al, 2001).…”

Crystallography and computational electronic structure investigations on 14-(3, 4, 5-trimethoxyphenyl)-14H-dibenzo[a,j]xanthene

“…Generally, the xanthene core compounds have been employed as dyes in laser technologies as well as in making of pH sensitive fluorescent materials for the visualization of biomolecules [4,5]. In addition to that, they show potential cytotoxic activity against colon cancer cell lines particularly on Colon-205 and Colon-502713 [6]. Several drugs synthesized from xanthene frame work have demonstrated its binding efficiency with DNA by intercalative mode and its knack as good radical scavengers [7,8].…”

Efficient one-pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives promoted by niobium pentachloride

“…The synthesis of xanthenes and their derivatives has received significant attention due to their various pharmacological activities, such as antibacterial and antifungal (Limsuwan et al, 2009;Omolo et al, 2011), analgesic and anti-inflammatory (Hafez et al, 2008;Banerjee et al, 2011), anti-viral (Jamison et al, 1990Naidu et al, 2012), antioxidant (Nishiyama et al, 1998), anti-cancer (Chatterjee et al, 1996;Song et al, 2013), cytotoxic (Bhattacharya et al, 2009) and antiproliferative properties (Kumar et al, 2010). These compounds have also been employed as sensitisers in photodynamic therapy (Neckers, 1989;Gutiérrez & García, 1998;Chang et al, 2008), in the food industry as additives (Tanaka, 2001;Chequer et al, 2012;Odo et al, 2012;Qi et al, 2012), in laser technologies (Ahmad et al, 2002;De et al, 2005) and as fluorescent materials for the visualisation of biomolecules (Knight & Stephens, 1989;Liu et al, 2001;Hilderbrand & Weissleder, 2007).…”