Synthesis and in vitro microbial evaluation of La(III), Ce(III), Sm(III) and Y(III) metal complexes of vitamin B6 drug

Refat, Moamen S.; Al-Azab, Fathi M.; Al-Maydama, Hussein M.A.; Amin, Ragab R.; Jamil, Yasmin M.S.

doi:10.1016/j.saa.2014.02.043

Cited by 19 publications

(5 citation statements)

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“…1,1-Oxalyl, 1,1-malonyl and 1,1-succinyl-bis-4-phenyl-thiosemicarbazide and all the metal Co(II), Cu(II), Zn(II) and Sn(II) complexes thermodynamic activation parameters of decomposition processes of the samples, namely activation energy, E * , enthalpy, ΔH * , entropy, ΔS * , and Gibbs free energy change of the decomposition, ΔG * , were evaluated graphically (Figures S13-S27) by employing the Coats-Redfern and Horowitz-Metzger relations [34]- [36]. All the thermodynamic parameters for the rest of materials, malonyl and Succinyl complexes were also calculated,.…”

Section: Kinetic Studiesmentioning

confidence: 99%

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Amin¹,

Elreedy²,

Alansi³

et al. 2016

OJIC

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The thermogravimetry (TG) and derivative thermogravimetry (DTG) have been used to study the thermal decomposition of some oxalyl (H 4 OxTSC), malonyl (H 4 MaTSC) and succinyl-bis-4-phenylthiosemicarbazide (H 4 SuTSC) ligands and their metal complexes using Horowitz-Metzger (HM) and Coats-Redfern methods. The kinetic thermodynamic parameters such as: E*, ΔH*, ΔS*and ΔG* are calculated from the DTG curves. The isolated complexes have the general composition [M 2 (L) (H 2 O) 6 ], where M=Cu(II), Zn(II), L=MaTSC and M=Co(II), Cu(II) or Sn(II) and L=Su TSC and [M 2 (L) (H 2 O) n ]·nH 2 O where M=Cu(II), Co(II) or Sn(II), L=OxTS or Ma TSC. The tested compounds show a good activity against four strains of bacteria Gram negative Escherichia coli, Pseudomonas aeruginosa species and gram-positive Bacillus cereus and Staphylococcus aureus.Keywords Metal (II) Complexes, Bis-Thiosemicarbazide, Thermogravimetric, Antibacterial Studies 1. Introduction Thiosemicarbazide and its derivatives have received considerable attention because of their pharamacological * Corresponding author.R. R. Amin et al. 90 properties [1]. Thiosemicarbazide complexes show a broad spectrum of anticancer activity [2] [3]. Also, thiosemicarbazide derivatives are of current interest with respect to their uses as analytical reagents for separations of metal(II) ions [4]-[7], analytical determination of metal ions [8] [9], and clinical analysis [10]. Most of these compounds have antifungal [11]-[12], antimicrobial [13] and antitumor activity [14]-[16], as well as radiopharmaceuticals applications [17]. Continuing our studies for the chemical and electrochemical synthesis of new metal complexes of ligands containing N, S and O atoms through the reaction of metal ions scarified from the anodic dissolution of metals [18] [19]. Our aim work in this paper to report novel complexes prepared from the reaction between bisthiosemicarbazi decompounds which have a good ability to form chelate complexes with transition metal [18]- [20]. We report here the thermal, spectral and biological evaluations of Co(II), Cu(II), Zn(II) and Sn(II) complexes for 1,1-oxalyl, malonyl and succinyl-bis-4-phenylthiosemicarbazide ligands. The modern spectroscopic investigations are used to elucidate the structure of the prepared materials. The thermal decomposition is also used to infer the structure of the metal complexes and to calculate the different thermodynamic activation parameters. Experimental The Organic Compounds1) Preparation of 1,1-Oxalylhydrazide: 1,1-oxalyldihydrazine was prepared by adding oxalyl chloride (7 gm, 0.05 mol) to alcoholic solution of hydrazine hydrate (5 gm, 0.1 mole). The reaction mixture was exothermic and left to cool with stirring. A white crystal precipitate was formed and washed with ethanol diethyl ether and left to dry.2) Preparation of 1,1-Oxalylbis (4-phenylthiosemicarbazide): It was prepared by adding phenylisothiocynate (2.8 gm, 0.02 mol) to an alcoholic solution of oxalic acid dihydrazide (1.18 gm, 0.01 mole). The reaction mixture was refluxed f...

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Section: Kinetic Studiesmentioning

confidence: 99%

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Amin¹,

Elreedy²,

Alansi³

et al. 2016

OJIC

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“…One of the most important representative elements from the lanthanides family is samarium. Sm 3+ ions are one of the most interesting ions to be analyzed due to their use in high-density optical storage, exquisite optical properties, and antibacterial properties [17,18].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Samarium Doped Hydroxyapatite, Ceramics for Medical Application: Antimicrobial Activity

Ciobanu

Iconaru

Popa

et al. 2015

Journal of Nanomaterials

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Samarium doped hydroxyapatite (Sm:HAp),Ca10-xSmx(PO4)6(OH)2(HAp), bionanoparticles with differentxSmhave been successfully synthesized by coprecipitation method. Detailed characterization of samarium doped hydroxyapatite nanoparticles (Sm:HAp-NPs) was carried out using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of samarium doped hydroxyapatite was assessed by cell viability. The antibacterial activity of the Sm:HAp-NPs was tested against Gram-negative bacteria (Pseudomonas aeruginosaandEscherichia coli) and Gram-positive bacteria (Enterococcus faecalisandStaphylococcus aureus). A linear increase of antimicrobial activity ofP. aeruginosahas been observed when concentrations of Sm:HAp-NPs in the samples withxSm=0.02were higher than 0.125 mg/mL. For Sm:HAp-NPs withxSm=0.05a significant increase of antibacterial activity onE. coliwas observed in the range 0.5–1 mg/mL. For low concentrations of Sm:HAp-NPs (xSm=0.05) from 0.031 to 0.125 mg/mL a high antibacterial activity onEnterococcus faecalishas been noticed. A growth of the inhibitory effect onS. aureuswas observed for all concentrations of Sm:HAp-NPs withxSm=0.02.

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“…It shows three absorbance peaks at (256, 292, and 324) nm in the UV region of the spectrum. This is the consequence of π–π* electronic transitions in the aromatic pyridine ring and n –π* transitions of −OH groups and nitrogen (−N) atoms of the aromatic ring of pyridoxine HCl. − …”

Section: Resultsmentioning

confidence: 99%

Exploration of Interactions between Pyridoxine HCl (Vitamin B₆) and {Hexadecyltrimethylammonium Bromide + Sodium Cholate (Trihydroxy Bile Salt)} Mixtures at T = (298.15 to 318.15) K: Physicochemical and Spectroscopic Approach

Sohal

Banipal

2021

J. Chem. Eng. Data

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Studies on the interactions of surfactant molecules with watersoluble vitamins have significance in pharmaceutical, biological, and industrial processes. Their mixed micelles can be used as a model for understanding the complex behavior encountered in food and biological assemblies. In this context, self-assembling properties of hexadecyltrimethylammonium bromide, HTAB, and sodium cholate, NaC, and their mixtures at molar fractions, α HTAB = (0.02, 0.04, and 0.13), have been investigated in water as well as in (1, 2, and 3) × 10 −4 mol•kg −1 pyridoxine HCl (aq) (vitamin B 6 ) solutions by employing various techniques. Critical micelle concentration, degree of ionization (g), and standard thermodynamic entities (ΔG 0 m , ΔH 0 m , and ΔS 0 m ) of micellization which state the physicochemical properties of the studied system have been determined from the conductivity measurements at 298.15, 308.15, and 318.15 K. The partial specific volume (φ v ), isentropic compressibility (κ s ), and partial specific isentropic compressibility (φ κ ) were evaluated using the density and sound velocity data. UV−visible absorption and fluorescence emission spectra were recorded for pyridoxine HCl (aq) solutions in the presence of HTAB and NaC and mixed (HTAB + NaC) surfactants at α HTAB = (0.02, 0.04, and 0.13) and at T = 298.15 K. Through dynamic light scattering studies, the hydrodynamic diameters (D h ) of aggregates have been examined.

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Synthesis and in vitro microbial evaluation of La(III), Ce(III), Sm(III) and Y(III) metal complexes of vitamin B6 drug

Cited by 19 publications

References 69 publications

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Evaluation of Samarium Doped Hydroxyapatite, Ceramics for Medical Application: Antimicrobial Activity

Exploration of Interactions between Pyridoxine HCl (Vitamin B₆) and {Hexadecyltrimethylammonium Bromide + Sodium Cholate (Trihydroxy Bile Salt)} Mixtures at T = (298.15 to 318.15) K: Physicochemical and Spectroscopic Approach

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Synthesis and in vitro microbial evaluation of La(III), Ce(III), Sm(III) and Y(III) metal complexes of vitamin B6 drug

Cited by 19 publications

References 69 publications

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Evaluation of Samarium Doped Hydroxyapatite, Ceramics for Medical Application: Antimicrobial Activity

Exploration of Interactions between Pyridoxine HCl (Vitamin B6) and {Hexadecyltrimethylammonium Bromide + Sodium Cholate (Trihydroxy Bile Salt)} Mixtures at T = (298.15 to 318.15) K: Physicochemical and Spectroscopic Approach

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About

Exploration of Interactions between Pyridoxine HCl (Vitamin B₆) and {Hexadecyltrimethylammonium Bromide + Sodium Cholate (Trihydroxy Bile Salt)} Mixtures at T = (298.15 to 318.15) K: Physicochemical and Spectroscopic Approach