Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives

Platinum(II) complexes containing long-chain hydrophobic N-alkyl-diamine ligands: Synthesis, characterization, molecular modeling, and cytotoxic activity

“…The IR frequencies and intensities were calculated at this same level of theory. 13 C NMR spectra were also predicted in methanol solution using the GIAO approach [21] at B3LYP/6-311 + G(2d,p)//6-31 G(d,p) level. The solvent effect was included by means of PCM continuum model [22] with dielectric constant of methanol (ε =32.63).…”

“…Lipophilic derivatives of platinum(II) have been investigated for their ability to enhance the cellular uptake of platinum in both cisplatinsensitive and resistant cell lines [13,14]. In a previous work [15], we were able to correlate the cytotoxic activity of platinum complexes containing diamine ligands having different carbon chains lengths with the lipophilicity of the compounds.…”

“…Fourier-transform Raman spectroscopy was carried out using a Brucker RFS 100 instrument equipped with an Nd 3 + /YAG laser operating at 1064 nm in the near infrared and a CCD detector cooled with liquid nitrogen with an average of 1000 scans and 4 cm − 1 of spectral resolution. 1 H NMR (300 MHz), 13 C NMR (75 MHz) and 195 Pt NMR (64 MHz) spectra were recorded on a Bruker spectrometer and were obtained by dissolving the complexes in DMSO-d 6 . The chemical shifts were expressed as δ (in ppm) from internal reference standard TMS ( 1 H NMR) and K 2 PtCl 6 ( 195 Pt NMR).…”

Platinum(II) compounds with chelating ligands based on pyridine and pyrimidine: DNA and protein binding studies

“…In fact the non-linear increased cleavage with increasing compound concentration suggests cleavage at multiple sites by the platinum compound. Table 1 Comparison of partition coefficient values for several reported platinum compounds using known methodology in water/n-octanol [31][32][33]. The effect of reducing agent (Ascorbic Acid, AA) on the cleavage of C4 was also assessed (Fig.…”

“…The partition coefficient (log P) is defined as the logarithmic ratio of the concentrations of a substance in a two-phase system consisting of two immiscible solvents [31][32][33]. When octanol and water is used as two immiscible solvents then P can be calculated using the following equation:…”