Synthesis and in vitro cytotoxic activity evaluation of novel heterocycle bridged carbothioamide type isosteviol derivatives as antitumor agents

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

“…Zhu et al prepared a series of novel carbothioamide-pyrazole derivatives and tested for their in vitro cytotoxic activities against four human tumor cell lines. Results indicated that compound 258 exhibited potent cytotoxicity (IC 50 = 6.51 µM) against Raji cell [ 163 ].…”

Crystal structure of N-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioamide, C21H29N3S

“…In addition, numerous adamantane derivatives were reported to exhibit potent anticancer [9,10], bactericidal, fungicidal [11,12] and antimalarial [13] activities. Moreover, various N-(1-and 2-adamantyl)carboxamides and N-(substituted)carbothioamides were reported to display diverse pharmacological activities [14][15][16][17]. As a part of our ongoing research interest in the chemotherapeutic [18][19][20][21] and structural [22,23] properties of adamantane derivatives, we recently reported the synthesis, antibacterial and hypoglycemic activities of the title compound [21], and we report herein its crystal structure.…”

Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents

“…The diterpene, isosteviol (Figure 1), bearing the distinctive tetracyclic skeleton of kaurene, exhibits wide biological activities including blood lipid control [4], anti-hypertension [5], heart-brain cell protection [6,7], blood glucose reduction [8,9] and antibacterial [10] and antiinflammation [11,12] effects [13,14,15,16]. It can be obtained as a metabolite of stevioside isolated from the leaves of the natural stevia plant [17]. Furthermore, the cytotoxic activities of isosteviol derivatives have attracted much attention in recent years.…”