Synthesis and in vitro characteristics of biogenic-derived hydroxyapatite for bone remodeling applications

Ragini, B.; Kandhasamy, Sivakumar; Jacob, Justin Packia; Vijayakumar, Sekar

doi:10.1007/s00449-023-02940-y

Cited by 2 publications

(1 citation statement)

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“…The FT-IR spectrum of nano-hydroxyapatite ( Figure 3 (Bb)) showed the stretching of the O‒H group close to 3200 cm −1 and the stretching and deformation of the phosphate ion (PO4) 3− . The bands referring to the phosphate ion were observed in a pronounced way at 1083 and 1037 cm −1 , referring to the asymmetric stretching; there was an attenuated band at 957 cm −1 , referring to the symmetric stretching of the phosphate; and there were three bands at 605, 567, and 464 cm −1 , referring to asymmetric deformation [ 66 , 67 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

Use of Plant Extracts in Polymeric Scaffolds in the Regeneration of Mandibular Injuries

de Oliveira,

Maia,

Massimino

et al. 2024

Pharmaceutics

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Severe loss of bone mass may require grafting, and, among the alternatives available, there are natural biomaterials that can act as scaffolds for the cell growth necessary for tissue regeneration. Collagen and elastin polymers are a good alternative due to their biomimetic properties of bone tissue, and their characteristics can be improved with the addition of polysaccharides such as chitosan and bioactive compounds such as jatoba resin and pomegranate extract due to their antigenic actions. The aim of this experimental protocol was to evaluate bone neoformation in experimentally made defects in the mandible of rats using polymeric scaffolds with plant extracts added. Thirty rats were divided into group 1, with a mandibular defect filled with a clot from the lesion and no graft implant (G1-C, n = 10); group 2, filled with collagen/chitosan/jatoba resin scaffolds (G2-CCJ, n = 10); and group 3, with collagen/nanohydroxyapatite/elastin/pomegranate extract scaffolds (G3-CHER, n = 10). Six weeks after surgery, the animals were euthanized and samples from the surgical areas were submitted to macroscopic, radiological, histological, and morphometric analysis of the mandibular lesion repair process. The results showed no inflammatory infiltrates in the surgical area, indicating good acceptance of the scaffolds in the microenvironment of the host area. In the control group (G1), there was a predominance of reactive connective tissue, while in the grafted groups (G2 and G3), there was bone formation from the margins of the lesion, but it was still insufficient for total bone repair of the defect within the experimental period standardized in this study. The histomorphometric analysis showed that the mean percentage of bone volume formed in the surgical area of groups G1, G2, and G3 was 17.17 ± 2.68, 27.45 ± 1.65, and 34.07 ± 0.64 (mean ± standard deviation), respectively. It can be concluded that these scaffolds with plant extracts added can be a viable alternative for bone repair, as they are easily manipulated, have a low production cost, and stimulate the formation of new bone by osteoconduction.

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Section: Resultsmentioning

confidence: 99%