Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Koketso J. Setshedi,
Richard M. Beteck,
Kayhan Ilbeigi
et al.
Abstract:Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and Leishmania. The corresponding diseases have afflicted humans for centuries. In an effort to combat kinetoplastid infections, a set of 21 chalcones was synthesized and evaluated for their in vitro anti-protozoal efficacy against Trypanosoma brucei, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and Leishmania infantum. To ensure safety, these compounds underwent a selectivity evaluation … Show more
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