Synthesis and in vitro antitumor activity of 1-(4-methylphenyl)-3-(morpholin-4-yl)-2-phenyl-1-R-propan-1-ol Hydrochlorides

Isakhanyan, A. U.; Gevorgyan, G. A.; Chshmarityan, S. G.; Nersesyan, L. E.; Agaronyan, A. S.; Danielyan, I. S.; Stepanyan, G. M.; Panosyan, G. A.

doi:10.1134/s1070428016040242

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Aminoalcohol and Oxime Synthesis1

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2022

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Cited by 3 publications

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“…In addition, the incorporation of N-benzyl substituents in the amino group is crucial for improved cytotoxic inuence and privileged antiproliferative characters. 107 Owing to the privileged biological potency of tertiary amino alcohols, 155,156 Gevorgyan et al 154…”

Section: Aminoalcohol and Oxime Synthesismentioning

confidence: 99%

Recent progress in the chemistry of β-aminoketones

Hammouda

Elattar

2022

RSC Adv.

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Section: Aminoalcohol and Oxime Synthesismentioning

confidence: 99%

Recent progress in the chemistry of β-aminoketones

Hammouda

Elattar

2022

RSC Adv.

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“…Tertiary aminoalcohols, i.e., cyclodol derivatives [3,4], have broad spectra of biological activity and provided a platform on which our search for potential biologically active agents among this series was based. A new series of tertiary aminoalcohols, i.e., derivatives of 4-(4-fluorophenyl)-and 4-(1,3-benzodioxol-5-ylmethyl)-substituted piperazines III-XV, were synthesized by reacting b-aminoketones I and II with alkyl(aryl)magnesium halides.…”

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confidence: 99%

Synthesis of Tertiary Piperazine Aminoalcohols and their Dihydrochlorides and their Influence on DNA Methylation Processes In Vitro

et al. 2021

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Tertiary piperazine aminoalcohols were synthesized by reacting 1-(4-butoxyphenyl)-3-(4-substituted piperazin-1-yl)-2-phenylpropan-1-ones with alkyl(aryl)magnesium halides. Some of the final compounds were converted into dihydrochlorides. The influence of the synthesized compounds on C-180 mouse tumor DNA methylation was studied in vitro by incubating drug solutions (3 ´10 -6 M) with tumor homogenates at 37°C (thermostatted) for 24 h. Rather high activity (51.6% inhibition of DNA methylation) was observed for 1-(4-butoxyphenyl)-3-[4-(4-fluoropheny)piperazin-1-yl]-1,2-diphenylpropan-1-ol containing a 1-phenyl radical. Introduction of a methoxy group into the ortho-position of the phenyl radical decreased the activity to 37.5%.

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