Synthesis and in vitro antiproliferative profile of novel isomeric aza-analogues of natural jaspine B

Novotná, Michaela; Raschmanová, Jana Špaková; Martinková, Miroslava; Pilátová, Martina; Kuchár, Juraj; Litecká, Miroslava; Jáger, Dávid

doi:10.1016/j.tet.2021.132570

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Novotná et al obtained new aza-derivatives of Jaspine B [ 107 ]. The basis for the use of the Jaspine B scaffold was its demonstrated ability to induce apoptosis in melanoma cell line SK-MEL-28 [ 108 ].…”

Section: The Most Potent Anti-melanoma Agent From Most Recent Studies...mentioning

confidence: 99%

“…The basis for the use of the Jaspine B scaffold was its demonstrated ability to induce apoptosis in melanoma cell line SK-MEL-28 [ 108 ]. Compound (43) exhibited the highest activity against melanoma cell line BLM with an IC 50 = 31.01 ± 0.89 µM/L, as compared to standard Cisplatin with an IC 50 = 32.18 ± 1.29 µM/L [ 107 ].…”

Section: The Most Potent Anti-melanoma Agent From Most Recent Studies...mentioning

confidence: 99%

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New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022

Kozyra

Krasowska

Pitucha

2022

IJMS

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Malignant melanoma (MM) is the most lethal skin cancer. Despite a 4% reduction in mortality over the past few years, an increasing number of new diagnosed cases appear each year. Long-term therapy and the development of resistance to the drugs used drive the search for more and more new agents with anti-melanoma activity. This review focuses on the most recent synthesized anti-melanoma agents from 2020–2022. For selected agents, apart from the analysis of biological activity, the structure–activity relationship (SAR) is also discussed. To the best of our knowledge, the following literature review delivers the latest achievements in the field of new anti-melanoma agents.

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Section: The Most Potent Anti-melanoma Agent From Most Recent Studies...mentioning

confidence: 99%

Section: The Most Potent Anti-melanoma Agent From Most Recent Studies...mentioning

confidence: 99%

New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022

Kozyra

Krasowska

Pitucha

2022

IJMS

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Stereoselective synthesis and anticancer profile of C-alkyl pyrrolidine-diols with a sphingoid base-like backbone

Pončáková

Fábian²,

Martinková³

et al. 2022

Tetrahedron

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Synthesis and in vitro antiproliferative profile of novel isomeric aza-analogues of natural jaspine B

Cited by 2 publications

References 33 publications

New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022

New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022

Stereoselective synthesis and anticancer profile of C-alkyl pyrrolidine-diols with a sphingoid base-like backbone

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