Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde

Abstract

Background: Design, identification, and synthesis of new antimicrobial agents along with preventive proceedings are essential to confront antibiotic-resistant pathogenic bacteria. Heterocyclic Schiff bases are biologically important compounds whose antimicrobial potentials have been proven to bacterial and fungal pathogens. Objectives: In this study, some quinoline Schiff bases were synthesized from condensation of 2-chloro3-quinolinecarboxaldehyde and aniline derivatives. Their inhibitory activities were evaluated against 6 gram-positive and 2 gram-negative bacterial pathogens. Methods: Disc diffusion, broth microdilution, and time-kill tests were applied according to the CLSI guidelines to determine IZD, MIC, and MBC values. Results: 2-Chloro-3-quinolinecarboxaldehyde Schiff bases could inhibit the growth of bacteria with IZDs of 7.5-19.8 mm, MICs of 256-2048 μg mL-1, and MBCs of 512 to ≥2048 μg mL-1. Conclusion: Moderate antibacterial effects were observed with heterocyclic Schiff bases. Complexation and structural changes can improve their antimicrobial properties.

Synthesis, structure diversity, and antimicrobial studies of Ag(i) complexes with quinoline-type ligands

“…38 Also, quinoline based derivatives are considered structural components of many medicines with antibacterial, antimalarial, and anticancer properties. [36][37][38][39][40][41][42][43][44][45][46] Generally, quinolines are commonly used in many aspects such as the production of herbicides, corrosion inhibitors, and sensors. 36,47 In addition, aromatic compounds with nitro groups, especially nitroquinoline derivatives, are frequently used in the manufacture of drugs, dyes, and explosives.…”

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities

“…Quinolines are derivatives of pyridine and are found in many biologically active natural [ 5 , 6 ] and synthetic [ 7 , 8 , 9 ] compounds. Their Schiff base derivatives have also been identified with various pharmaceutical activities [ 10 , 11 ]. Although some free Schiff base ligands are known to be bioactive, literature has shown that incorporating metal in such ligands enhances their activities [ 12 , 13 ].…”