Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines

Chamakura, Upendar Reddy; Sailaja, E.; Dulla, Balakrishna; Kalle, Arunasree M.; Bhavani, S.; Dandela, Rambabu; Kapavarapu, Ravikumar; Rao, Mandava V. Basaveswara; Pal, Manojit

doi:10.1016/j.bmcl.2014.01.044

Cited by 10 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the pyridine skeletons have emerged as integral backbones of over 7000 existing drugs [1,2] . Also, the pyridine ring is an integral part of anti‐inflammatory and anticancer agents [3–8] . In association with those, pyridinone and their derivatives display abroad spectrum of potential biological processes and have considerable pharmacological and chemical importance [9–11] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 4‐Hydroxy‐2‐pyridinone Derivatives and Evaluation of Their Antioxidant/Anticancer Activities

et al. 2021

View full text Add to dashboard Cite

A simple approach was applied for the regioselective synthesis of various pyridine‐2‐one derivatives or annulated pyridine as novel heterocyclic systems from the reaction of dehydroacetic acid (DHA) with mono‐ or bidentate nucleophile as with benzylamine and/or phenylenediamines in dichloromethane followed by transformation with different halo‐compounds in refluxing 1,4‐dioxane has been achieved in moderate to excellent yields (48‐93 %). In addition, DFT studies of the key synthesized compounds were carried out for confirmed proposed mechanisms. The newly synthesized compounds were screened for their in‐vitro inhibition activities against mammary gland breast cancer (MCF‐7) and human prostate cancer (PC‐3) using the MTT colorimetric method. Also, the target synthesized compounds were evaluated as antioxidant agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis of 4‐Hydroxy‐2‐pyridinone Derivatives and Evaluation of Their Antioxidant/Anticancer Activities

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Some new heterocyclic compounds containing nitrogen atom have been synthesized and used as antiparkinsonian 3 , antitumor 4,5 , antimicrobial [6][7][8] and antiinflammatory activities 9,10 . Recently, some of the pyridine derivatives were synthesized and evaluated as antimycobacterial 11,12 , new class of cytotoxic Hsp90 inhibitors 13 , antitumor 14 , antiproliferative 15 and antiinflammatory [16][17][18][19] agents. They are also evaluated as analgesic 20,21 and antioxidant 22 agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anti-Inflammatory Activities of Some New Substituted Benzocarboxamide Pyrimidine Derivatives Using N-(4-Acetylphenyl)-5-chloro-2-methoxybenzamide as Starting Material

Hussain¹,

Abdulla²,

Amr³

et al. 2014

Asian J. Chem.

View full text Add to dashboard Cite

A series of substituted pyrimidine derivatives (2-6) were prepared from corresponding chalcones, which were prepared from N-(4acetylphenyl)-5-chloro-2-methoxybenzamide as starting material. The structure assignments of the newly synthesized compounds are based on chemical and spectroscopic evidence. The pharmacological screening showed that many of these compounds have less toxicity and good anti-inflammatory activities.

show abstract

“…Enantiopure diheteroarylmethanols are ubiquitous and valuable intermediates and structural motifs in numerous medicines, agrochemicals, and biologically active compounds (Figure ). − It is thus of substantial importance to develop efficient protocols for enantioselective synthesis of these structures . Among the developed synthetic strategies, the catalytic asymmetric reduction of ketones represents the most potential approach from the practical and atom-economic points of view.…”

mentioning

confidence: 99%

Asymmetric Transfer Hydrogenation of Densely Functionalized Diheteroaryl and Diaryl Ketones by a Ru-Catalyst of Minimal Stereogenicity

Lü

et al. 2020

Org. Lett.

View full text Add to dashboard Cite

A highly enantioselective asymmetric transfer hydrogenation (ATH) of densely functionalized diheteroaryl and diaryl ketones was developed using Ru-catalysts of minimal stereogenicity. Various ketone substrates with structurally and electronically similar groups attached to the prochiral centers were reduced successfully in good to excellent enantioselectivities and yields. This protocol provides practical and efficient access to chiral diheteroarylmethanols and benzhydrols, which are key intermediates in pharmaceuticals and biologically active compounds.

show abstract

Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines

Cited by 10 publications

References 27 publications

Synthesis of 4‐Hydroxy‐2‐pyridinone Derivatives and Evaluation of Their Antioxidant/Anticancer Activities

Synthesis of 4‐Hydroxy‐2‐pyridinone Derivatives and Evaluation of Their Antioxidant/Anticancer Activities

Synthesis and Anti-Inflammatory Activities of Some New Substituted Benzocarboxamide Pyrimidine Derivatives Using N-(4-Acetylphenyl)-5-chloro-2-methoxybenzamide as Starting Material

Asymmetric Transfer Hydrogenation of Densely Functionalized Diheteroaryl and Diaryl Ketones by a Ru-Catalyst of Minimal Stereogenicity

Contact Info

Product

Resources

About