Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides

Michael Cyclization of Polarized Systems: Synthesis and in vitro Anti-Diabetic Evaluation of Some Novel Pyrimidine, Pyridine, Pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives

“…[12][13][14][15][16] From the structure-activity relationships, it is revealed that the selected group of heterocyclic skeletons is important for anti-diabetic studies, which supports the previous results. For instance, the novel compounds 5, 8, 10, 11a and 11b shared similar chemical features and functional groups, such as the presence of hydroxyl and methoxy groups were evaluated for their potential α-glucosidase inhibitory activity.…”

“…Pyrimidines, as the most important nitrogen-containing heterocyclic compounds, are of chemical and pharmacological interest. Many studies have been shown that compounds containing the pyrimidine ring possess antidiabetic, antibacterial, antifungal, antimalarial, and anticonvulsant activities, [12][13][14][15][16] and anticancer activities, [17,18] and many of pyrimidine compounds were reported to act as calcium channel blockers, [19] and as potential central nervous system (CNS) depressants. [20,21] Also, Pyrazoline derivatives widely occur in the environment, in the form of alkaloids, vitamins and pigments as constituents of plant and animal cell.…”

Synthesis and Biological Evaluation of Some Novel Polysubstituted Pyrimidine Derivatives as Potential Antimicrobial and Anticancer Agents

“…Being a building unit of DNA and RNA, pyrimidine derivatives were found to be associated with a variety of chemotherapeutic effects including antimicrobial [6 -10], antitubercular [11], antifungal [12], antimalarial [13], and antiviral [14,15] activities. Furthermore, pyrimidine-containing compounds were reported to contribute to a variety of anticancer potentials including antitumor [16], antineoplastic [17], antiproliferative [18,19], thymidylate synthase and dihydrofolate reductase inhibitory [20], angiogenesis inhibiting [21], and cyclin-dependent kinase inhibitory [22] activities.…”

Polyethylene glycol (PEG-400) as a medium for novel and efficient synthesis of 2-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives

“…In past decades, polyethylene glycol (PEG-400) has acquired significance as an eco-friendly solvent in many organic reactions, and economically viable, non-hazardous, and nontoxic green solvent. On the other hand, PEG also acts as a phase transfer catalyst and is used in many synthetic organic transformations [16] such as oxidation, reduction reactions [17], and Suzuki cross-coupling reaction [18], Wacker reaction [19], and Heck reaction [20]. …”