Synthesis and In vitro and In silico Anti-inflammatory Activity of New
Thiazolidinedione-quinoline Derivatives
Sandra Elizabeth Barbosa da Silva,
José Arion da Silva Moura,
Jeann Fabiann Branco Júnior
et al.
Abstract:Background:
Inflammation is a series of complex defense-related reactions. The inflammation
cascade produces various pro-inflammatory mediators. Unregulated production of these
pro-inflammatory mediators can lead to a wide range of diseases, including rheumatoid arthritis,
sepsis, and inflammatory bowel disease. In the literature, the anti-inflammatory action of quinoline
and thiazolidinedione nuclei are well established, alone, and associated with other nuclei.
The synthesis of hybrid molecules is a strategy … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.