Abstract:In the present work, a small library of few 1‐deoxysphingolipid ceramides has been designed and synthesized via an efficient UGI multicomponent reaction. The deoxy sphingosine intermediate (10) synthesized via Grignard reaction and olefin metathesis reaction was used as the amine component with cyclohexyl isocyanide and various aldehydes. The butyric acid has been used as an acid component which may turn out be an advantage due to the chemo preventive properties of the acid formed after the partial hydrolysis … Show more
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