Synthesis and in Silico Analysis of Novel 1,2,4- Triazolylamides as Potential Antifungals

Abstract

The lead hybridization concept was used to synthesize the series of 40 novel compounds having a 1,2,4-triazole moiety allied to various bioactive amines via carboxamide linkage. One pot two step reaction protocol was followed using K 2 CO 3 as novel and efficient catalyst. The titled compounds were made through preliminary screening for antifungal potential against various phytopathogenic fungi. Compounds 1a, 5a, 9a, 5b and 9b showed appreciable fungitoxicity against most of the test fungi. The best result was shown by compound 1a against Drechslera oryzae, which was comparable to the standard triazole fungicide, propiconazole. Lipophilicity (log P) was taken as critical factor that amend the bio-efficacy of the test compounds.