Synthesis and Identification of some new Derivatives Oxazole, Thiazole and Imidazol from Acetyl Cysteine

sdeek, ghufran thanoon; Mauf, Ruwa M.; Saleh, Mohanad

doi:10.21608/ejchem.2021.88755.4267

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Synthesis of bis (O-methoxy benzylidine imine) (6) (22) (0.02 mole) of O-methoxy benzaldehyde is mixed with (0.01 mole) of (hydrazine hydrate) in the presence of (80%) acetic acid using (30 ml) ________________________________________________ Egypt. J. Chem.…”

Section: 2mentioning

confidence: 99%

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Saeed

Saleh

Sadeek³

2023

Egypt. J. Chem.

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In this paper, a new series of substituted 1, 2,4-triazines was prepared by reacting 4-amino sulfanilic acid with substituted benzaldehyde to form the corresponding Schiff base compounds (1-5), and then reacting two moles of O-methoxy benzaldehyde with hydrazine to form a compound ( 6) and these compounds reacted with Schiff base (1-5) by applying the Diels-alder reaction in the presence of benzene as a solvent and refluxed it to cyclized into substituted of 1,2,4-triazines derivatives (7-11). Depending on the physical and spectroscopic properties of the prepared compounds that were identified, infrared spectroscopy and nuclear magnetic resonance were used. An evaluation of the biological activity of the prepared compounds was conducted and it gave anti-bacterial results, such as gram-positive and gram-negative when compared with known antibiotics.

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Section: 2mentioning

confidence: 99%

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Saeed

Saleh

Sadeek³

2023

Egypt. J. Chem.

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“…Color of new complexes ranged from brown, green to dark brown according to metals and ligands. Also, most of melting point are decomposed during measuring [20] b. FT-IR spectra Also, FTIR measurements were subjected to confirm the structures of new complexes. Most of characteristic bands that are included in FTIR spectra were listed in table 3.…”

Section: A Chns Analysis and Physical Propertiesmentioning

confidence: 99%

Preparation of New Complexes of Bivalent Manganese, Iron, Cobalt, and Nickel with Mixed Ligands of Ciprofloxacin (Cip) and Metronidazole (Met) or 4-Aminoantipyrine (4AAP) with Study of Their Chemical, Physical Properties and Antibacterial Activity

et al. 2022

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Synthesis of mixed metal complexes were done through reaction of two drugs such as antipyrine, or ciprofloxacin with Metronidazole to have eight complexes. Physical, chemical and antibacterial activity of new complexes were studied. These mixed ligands were further coordinating with bivalent transition metals in a metal: ligands mixture ratio 1:1. These complexes were characterized by using elemental analysis and physical properties, in addition molar conductance in DMF which showed non-electrolytic behavior. FT-IR spectra revealed absorption bands for new ligands and metal complexes that agreed with the propose structures and the electronic spectra verified that these complexes display six-coordinate octahedral geometry. Antibacterial activity showed good results.

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“…On the other hand, other studies illustrated that oltipraz protects against carcinogenesis of many organs, in addition to its chemoprotective activity against variety of carcinogens. [11,12,13,14]. It was also consideration that a pharmacophore containing 1,2-dithiole-3-thione moiety capable of improving insulin sensitivity under the hyperosmotic stress condition [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Multi-cyclic Sulfhydryl Donor Compounds Containing 1,2-dithiol-3-thione moiety

2021

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1,2-Dithiol-3-thiones are a sulfur containing five membered heterocyclic compounds, which constitute an important class of biologically active compounds owing to their ability to release sulfhydryl (SH) group. In this research a new series of multi-cyclic compounds, containing 1,2-dithiol-3-thione moiety, was synthesized. To pursue this goal, five chalcones (1a-e) were synthesized via the condensation of 1-tetralone with aromatic aldehydes under the influence of 5% ethanolic sodium hydroxide solution. These chalcones were converted to β-ketoesters (2a-e) via its reaction with ethyl acetoacetate in presence of 5% ethanolic sodium hydroxide solution. The thionation of these β-ketoesters with phosphorous penta sulfide in xylene afforded the titled compounds (3a-d). The chemical structures of the synthesized compounds were elucidated by the physical and spectral (IR and NMR) data.

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Synthesis and Identification of some new Derivatives Oxazole, Thiazole and Imidazol from Acetyl Cysteine

Cited by 5 publications

References 7 publications

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Preparation of New Complexes of Bivalent Manganese, Iron, Cobalt, and Nickel with Mixed Ligands of Ciprofloxacin (Cip) and Metronidazole (Met) or 4-Aminoantipyrine (4AAP) with Study of Their Chemical, Physical Properties and Antibacterial Activity

Synthesis of Some Multi-cyclic Sulfhydryl Donor Compounds Containing 1,2-dithiol-3-thione moiety

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