Synthesis and In Vitro Characterization of Carboxymethyl Chitosan-CBA-Doxorubicin Conjugate Nanoparticles as pH-Sensitive Drug Delivery Systems

Functionalization of chitosan with carboxylic acids and derivatives of them: Synthesis issues and prospects of practical use: A review

“…Another approach to the modification of chitosan with acid chlorides consisted in the interaction of carboxy methylchitosan with 4-formylbenzoyl chloride in the presence of triethylamine as HCl acceptor. The grafted derivative was then utilized to connect a doxorubicin molecule with the main polymer matrix in DMSO medium [192] (Figure 15). Here, grafted 4-formylbenzoyl amide played a role of the anchor residue in order to connect doxorubicin, which was released later in a tumor.…”

“…The drawback of this approach was in the use of toxic hydrazine. The use of hydrazide for the connection of the antitumor drug residue instead of azomethines from aldehyde as in [192] seemed to be due to the lesser electrophilic activity of the ketone fragment in daunorubicin. Graphene oxide nanoparticles, due to the presence of the 'terminal' COOH groups, can also graft onto chitosan in DMFA medium under ultrasound treatment, utilizing a condensing system such as dicyclohexylcarbodiimid/4-aminopyridine [204].…”

Synthesis of thiolated, PEGylated and POZylated silica nanoparticles and evaluation of their retention on rat intestinal mucosa in vitro

“…Several types of nanoparticles have been shown to have great potential as drug delivery systems (Nguyen et al, 2016;Hu et al, 2017;Davoudi et al, 2018). Siew et al (2012) developed nanoparticles based on mucoadhesive quaternary ammonium palmitoyl glycol chitosan.…”

Synthesis, antitumor activity and molecular mechanism of doxorubicin conjugated trimethyl-chitosan polymeric micelle loading Beclin1 siRNA for drug-resisted bladder cancer therapy

“…Numerous studies have reported the preparation and biomedical properties of modied chitosan such as gra-copolymerization, alkylation or multiple alkylation, carboxymethylation, michael addition and direct conjugation to chemotherapeutics as well as peptides or proteins. [24][25][26][27][28][29][30][31][32][33][34] Chitosan derivatives, N-quaternization modied chitosan, i.e. N,N,N-trimethyl chitosan (TMC) achieves considerable attention as a drug and gene carrier because of its physiochemical stability, biocompatibility, synthetic feasibility and controllable cationic charge as well as its water-solubility via regulation of its hydrophilic and hydrophobic groups.…”