Synthesis and in vitro biochemical properties, DNA binding and DNA cleavage ability of copper complexes of hydroxyflavone derivatives of novel organosulfur compounds as therapeutic agent

Synthesis of Copper and Cobalt complexes with a Hydrothermal Method and Their Applications in Antibiological Activity

“…[17][18][19] At the same time, it is also involved in a variety of metabolic pathways, such as mitochondrial respiration, free radical scavenging and iron absorption. [20,21] Its toxicity is based on the direct production of reactive oxygen species (ROS) that cleave DNA and RNA, and its distribution and homeostasis can be highly regulated. [22,23] Studies suggest that copper is an essential cofactor for tumor angiogenesis, because most tumor growth and metastasis depend on angiogenesis, and angiogenesis requires a specific amount of copper.…”

“…In coordination compounds, the transformation from oxidized Cu + to Cu 2+ plays an important role in chemistry and is also used as a catalyst in various biochemical reactions [17–19] . At the same time, it is also involved in a variety of metabolic pathways, such as mitochondrial respiration, free radical scavenging and iron absorption [20,21] . Its toxicity is based on the direct production of reactive oxygen species (ROS) that cleave DNA and RNA, and its distribution and homeostasis can be highly regulated [22,23] .…”