Abstract:Combretastatins-A4 (CA-4) is a natural product with extraordinary anticancer activity, which was isolated from the South African Tree-Combretum caffrum. However, the cis-isomer exhibits strong antitubulin activity only, but the cis-isomer tends to isomerize the inactive trans-isomer. In this paper, an additional pyrrolidone ring system was used to replace the cis double bond to arrest the cis-conformation. Thus, four new compounds of 3,4-diaryl pyrrolediones and 3,4-diaryl pyrrolones as CA-4 analogues were syn… Show more
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