Synthesis and in vitroAntimicrobial Activity of Nalidixic Acid Hydrazones

Abstract

A series of nalidixic acid‐based hydrazones have been synthesized and evaluated for their in vitro antimicrobial activity using the broth microdilution method against a panel of reference strains of microorganisms, including Gram‐positive bacteria, Gram‐negative bacteria, and fungi belonging to yeasts Candida spp. and molds Aspergillus spp., Penicillium spp., and Rhizopus spp. Nalidixic acid derivatives were obtained by condensation reaction of nalidixic acid hydrazide with substituted (hetero)aromatic aldehydes. All compounds have been characterized by 1H NMR and 13C NMR spectra. The antimicrobial activity indicated that compound with indole substituent could be a promising lead for future development of active antifungal agents.

Design, synthesis, and in vitro antimicrobial activity of hydrazide–hydrazones of 2‐substituted acetic acid

“…It is worth to stress that in our previous research, hydrazide–hydrazones of substituted benzoic acids showed significant activity against Gram‐positive bacteria . In particular, N ‐[(2‐hydroxy‐3,5‐diiodophenyl)methylidene]‐3‐methoxybenzhydrazide displayed activity much higher than commonly used chemotherapeutics against Bacillus spp . The above‐mentioned findings further support the growing importance of the synthesis of hydrazide–hydrazones derivatives.…”

“…Recently, we reported interesting results concerning the synthesis and antibacterial activity of hydrazide–hydrazones . It is worth to stress that in our previous research, hydrazide–hydrazones of substituted benzoic acids showed significant activity against Gram‐positive bacteria .…”

New hydrazide–hydrazones of isonicotinic acid: synthesis, lipophilicity and in vitro antimicrobial screening

“…Furthermore, recently we have reported interesting studies concerning the antimicrobial activity of hydrazide–hydrazones . A significant antibacterial activity, with greater efficacy than commonly used antibiotics, was observed with nitrofurazone analogues containing hydrazide–hydrazone moiety .…”

New Hydrazides and Hydrazide‐Hydrazones of 2,3‐Dihalogen Substituted Propionic Acids: Synthesis and in vitro Antimicrobial Activity Evaluation

“…In our previous articles, we described the synthesis of hydrazide‐hydrazone derivatives which showed significant antibacterial activity. [ ][ ] Particularly some of hydrazide‐hydrazones of 3‐methoxybenzoic acid and 4‐ tert‐ butylbenzoic acid showed higher antibacterial activity than commonly used antibiotics against Bacillus spp . In addition to this hydrazide‐hydrazones of 2‐substituted acetic acids displayed high bactericidal activity against a panel of Gram ‐positive bacterial strains …”