Synthesis and Hypolipidemic Activity of N‐Substituted Phthalimides. Part 5.

Abstract

9 examples) including novel triazolylphthalimides are synthesized by amination of phthalic anhydride. All the compounds obtained possess hypolipidemic activity. Compound (IIIb), the most active one, displays an excellent and quite promising hypolipidemic activity. -(SENA, V. L. M.; SRIVASTAVA*, R. M.; SILVA, R. O.; LIMA, V. L. M.; Farmaco 58 (2003) 12, 1283-1288; Dep. Quim. Fundam., Univ. Fed. Pernambuco, 50670 Recife, Brazil; Eng.) -M. Kowall 13-068

Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents

“…Mp Lit. (Sena et al, 2003): 269.7-270.4 °C. 1 H NMR (300 MHz, DMSO-d 6 ): δ 8.44 (s, 2 H, H-3′, H-5′), 7.84 (d, 2 H, J = 7.5 Hz, ArH), 7.74 (d, 2 H, J = 7.5 Hz, ArH).…”

Synthesis, structural and conformational study of selected N-substituted phthalimides

“…Imides synthesis is of widespread interest as several derivatives of this heterocyclic unit have been found to possess important applications in biology [1][2][3][4][5][6][7], synthetic [8][9][10] and polymer chemistry [11].…”

“…Phthalimides are directly obtained from these general methods, but they have also been obtained from a number of unusual starting materials and methods [3][4][5][6][12][13][14][15][16]. The reaction of potassium phthalimide with halogenoalkanes and with a variety of other alkylating agents leads to N-alkylphthalimide.…”