Synthesis and hypoglycemic activity of Bis(L-malato)oxovanadium(IV)

Gorodetskiĭ, V K; Tochilkin, A. I.; Belayeva, N. F.; Kovel'man, I. R.; Korovkin, B. F.

doi:10.1134/s1990750811030048

Cited by 3 publications

(1 citation statement)

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“…Moreover, these acids and their ability to complexation with biologically active d-electron metal ions may be useful to design new generation drugs. These types of complexes can be suitable in chelation therapy for metal ions such as copper(II) ions [33][34][35]. The presence of an asymmetric hydroxyl group relative to the carboxyl group offers the opportunity to create different ion-dipol orientations in complex formation with metal ions: mononuclear and polynuclear species [24,36].…”

Section: Introductionmentioning

confidence: 99%

Influence of d-Electron Divalent Metal Ions in Complex Formation with L-Tartaric and L-Malic Acids

et al. 2021

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Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions (copper, cobalt, nickel) were investigated. Potentiometric measurements have been performed in aqueous solution with computer analysis of the data for determination of the stability constants of complexes formed in the studied systems. The coordination mode of the complexes was defined using spectroscopic methods: electron paramagnetic resonance (EPR), ultraviolet-visible (UV-Vis), circular dichroism (CD), and infrared (IR). Results of the equilibrium studies have provided evidence for the formation of dimers with copper(II) ions and monomers with cobalt(II) and nickel(II) ions.

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