Synthesis and Herbicidal Activity of 1-Arylalkyl-3-pyrrolin-2-one Derivatives

Highly Efficient Synthesis of 3a,6a-Dihydrofuro[2,3-b]furans via a Novel Bicyclization

“…Compound 5a could be well converted into multisubstituted furan 6a in 95% yield in the presence of HCl (aq) in CH 2 Cl 2 at room temperature in 10 min. Much to our satisfaction, the 3-pyrrolin-2-one 7a (for crystallographic data, see SI) was smoothly obtained from 5a in 70% yield in HCONH 2 at 90 °C in 5 h. The 3-pyrrolin-2-one derivatives are of great importance owing to their wide range of biological activities and as synthons in the preparation of bile pigments and their derivatives …”

Efficient Preparation of [2‐13C]‐ and [3‐13C]‐3‐Cyano‐4‐methyl‐3‐pyrrolin‐2‐one

“…They are very useful in the field of crop protection. [8] 4-Substituted 1,5-diphenylpyrrolin-2-ones show antimicrobial and antineoplastic activities. [9] 3-Acyl-3-pyrrolin-2-ones bearing long-chain alkoxy substituents possess useful neurotogenic properties and are members of a class of chemotherapeutics used to treat neuroblastoma tu-mours.…”

Synthesis and herbicidal activity of new oxazinone herbicides with a long‐lasting herbicidal activity against Echinochloa oryzicola

“…Among them, a study carried out by Ohba et al 5 showed that 3‐phenyl‐ N ‐(α,α′‐dimethylbenzyl)‐2‐pyrrolinone compounds exhibit a potent activity against Echinochloa species as well as against some other broad‐leaved weeds. We examined structural modification of such pyrrolinone compounds and synthesized a number of analogues, among which, a benzothiazolyl compound, MI‐2826 (Fig 1, 1 ) was selected as a candidate to control Echinochloa species and some annual broad‐leaved weeds 6. However, repeated biological field tests showed that this candidate occasionally caused phytotoxicity in the crop, such as shortening the length and decreasing the supporting ability of roots, so causing a slanting of the seedling stems.…”