Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer

Kwan, Kim H.; Burvenich, Ingrid; Centenera, Margaret M.; Goh, Yit Wooi; Rigopoulos, Angela; Dehairs, Jonas; Swinnen, Johannes V.; Raj, Ganesh V.; Hoy, Andrew J.; Butler, Lisa M.; Scott, Andrew; White, Jonathan M.; Ackermann, Uwe

doi:10.1016/j.nucmedbio.2020.11.007

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…There is a significant difference between PE and glycerophosphatidylethanolamine (and their ratios) between PCa and benign prostatic hyperplasia (136), and in vitro 31 P nuclear magnetic resonance can be used to detect phospholipid metabolites to assist in the diagnosis of PCa (137). Moreover, phospholipids can be radiolabeled and developed as PET imaging agents for PCa (138). Gradients of changes in the intensity of various lipids, such as PC, PS, PI, phosphatidic acid and cardiolipin, are associated with increases in Gleason scores (139).…”

Section: Phospholipid Metabolism In Prostate Cancermentioning

confidence: 99%

New insights into lipid metabolism and prostate cancer (Review)

et al. 2023

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Prostate cancer (PCa) is the most common malignant tumor of the male urological system and poses a severe threat to the survival of middle-aged and elderly males worldwide. The development and progression of PCa are affected by a variety of biological processes, including proliferation, apoptosis, migration, invasion and the maintenance of membrane homeostasis of PCa cells. The present review summarizes recent research advances in lipid (fatty acid, cholesterol and phospholipid) metabolic pathways in PCa. In the first section, the metabolism of fatty acids is highlighted, from formation to catabolism and associated proteins. Subsequently, the role of cholesterol in the pathogenesis and evolution of PCa is described in detail. Finally, the different types of phospholipids and their association with PCa progression is also discussed. In addition to the impact of key proteins of lipid metabolism on PCa growth, metastasis and drug resistance, the present review also summarizes the clinical value of fatty acids, cholesterol and phospholipids, as diagnostic and prognostic indicators and therapeutic targets in PCa. Contents1. Introduction 2. Fatty acid metabolism in prostate cancer 3. Cholesterol and its ester metabolism in prostate cancer 4. Phospholipid metabolism in prostate cancer 5. Lipid metabolism and the diagnosis and treatment of prostate cancer 6. Conclusions and future perspectives

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Section: Phospholipid Metabolism In Prostate Cancermentioning

confidence: 99%

New insights into lipid metabolism and prostate cancer (Review)

et al. 2023

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Nanotechnological strategies for prostate cancer imaging and diagnosis

et al. 2022

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Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer

Cui

Luo

Liu

et al. 2023

Journal of Pharmacy and Pharmacology

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Objectives To explore the underlying mechanism of total flavonoids of Litchi seed (TFLS) in treating prostate cancer (PCa). Methods Cell Counting Kit-8 (CCK-8), EdU incorporation assay, trypan blue dye assay and colony formation assay were employed to evaluate the effect of TFLS on PCa in vitro. The xenograft mouse model was established to explore the anti-tumour effect of TFLS in vivo. Alterations in the metabolic profiles of the PC3 cells and mouse serum were obtained by untargeted metabolomics. Combination with metabolomics analysis and network pharmacology strategies, the potential targets were predicted and further validated by RT-qPCR. Key findings TFLS attenuated PCa progression both in vitro and in vivo. Metabolomics results yielded from cells and serum indicated that the anti-cancer effect of TFLS was correlated with synergistic modulation of five common metabolic pathways including glycerophospholipid metabolism, arginine and proline metabolism, glycine, serine and threonine metabolism, tryptophan metabolism and steroid biosynthesis. Using in silico prediction and RT-qPCR analysis, we further revealed that TFLS exerted anti-PCa activities via regulating the expressions of nine genes, including MAOA, ACHE, ALDH2, AMD1, ARG1, PLA2G10, PLA2G1B, FDFT1 and SQLE. Conclusions TFLS suppressed tumour proliferation in PCa, which may be associated with regulating lipid and amino acid metabolisms.

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Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer

Cited by 3 publications

References 27 publications

New insights into lipid metabolism and prostate cancer (Review)

New insights into lipid metabolism and prostate cancer (Review)

Nanotechnological strategies for prostate cancer imaging and diagnosis

Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer

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