Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers

Synthesis and Pharmacological Evaluation of 1-Alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]piperidine-4-carboxamide Derivatives as Novel Antihypertensive Agents

“…After the initial spontaneous beat rate was recorded, test compounds dissolved in dimethyl sulfoxide (DMSO) and diluted with saline to the desired concentration were added to the bath solution cumulatively at 30-min intervals to construct a concen-tration-response curve. The EC 30 value for the concentration of the compounds producing a 30% reduction from initial spontaneous beat rate was determined via linear regression.…”

Photoredox Catalyzed Intramolecular Fluoroalkylarylation of Unactivated Alkenes

“…Carbocycles such as tetralin are found in many natural products and bioactive compounds (Figure ), and it is reasonable to consider that their fluoroalkylated analogues might exhibit altered potency However, the approaches for their preparation are extremely limited. So far only one example involving a copper catalyzed carbo trifluoromethylation of alkenes to introduce CF 3 has been reported by the Sodeoka group .…”