“…Currently, the best reported synthesis of thieno[2,3- d ]pyrimidin-4(3 H )-ones requires stoichiometric catalysts and multiple steps, including a Knoevenagel condensation, followed by a Gewald reaction, and heat-promoted cyclization. − To improve the synthetic efficiency of this reaction, we envisioned coupling the three steps into a one-pot synthesis (Scheme ). This four-component reaction of a ketone, ethyl cyanoacetate, S 8 , and formamide is predicted to have the advantage of a multicomponent reaction (MCR), including no intermediate isolation and a single purification step, which would be a greener synthetic strategy than what is currently available. − …”