Synthesis and evaluation of the antioxidant activity of new spiro-1,2,4-triazine derivatives applying Ag/Fe3O4/CdO@MWCNT MNCs as efficient organometallic nanocatalysts

Abstract

We applied the Petasites hybridus rhizome water extract as green media so that Ag/Fe3O4/CdO@ multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe3O4/CdO@MWCNTs MNCs) could be prepared. We also evaluated its activity by using in the one-pot multicomponent reaction of acetophenones, diethyl oxalate, ammonium acetate, and activated carbonyl compounds such as ninhydrin, isatin and acenaphthylene-1,2-dione, and malononitrile and hydrazoyl chlorides in an aqueous medium at room temperature for the generation of spiro-1,2,4-triazines as new derivatives with tremendous output. Moreover, reducing organic pollutants from 4-nitrophenol (4-NP) was carried out by generating Ag/Fe3O4/CdO@MWCNTs in water at room temperature. The results displayed that Ag/Fe3O4/CdO@MWCNTs reduced pollutants of organic compounds in a short time. The synthesized spiro-1,2,4-triazines have NH and OH functional groups having acidic hydrogen with high antioxidant power. Also, the spiro-1,2,4-triazines exhibited antimicrobial ability. For this purpose, the disk diffusion method was applied and two kinds of bacteria, Gram-positive and Gram-negative, were employed for the analysis. Furthermore, we applied functional theory-based quantum chemical methods in order to better understand reaction mechanism density. To generate spiro-1,2,4-triazines, the applied process showed many properties such as reactions with short time, products with good yields, and simple extraction of catalyst from a mixture of reactions.

Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery

“…For comprehensive coverage of synthetic protocols, readers are recommended to consult excellent reviews by Goel et al 32 The recent article published by Ezzatzadeh et al described the imidazopyrimidine synthesis by a multicomponent reaction. 34 Fig. 2 Structural representation of (3) lapatinib, (4) gefitinib, (5) vandetanib, and (6) erlotinib.…”

One pot multicomponent reaction of curcumin: Green synthesis of novel 1,4‐dihydropyridine‐2,3‐dicarboxylates

“…Among the metal oxide nanoparticles, Fe 3 O 4 magnetic nanoparticles (MNPs) are notable for their enormous surface area, simplicity in reaction removal, and reusability in MCRs [31a, b, 33, 34]. Recent research has focused on the development of novel and uncomplicated techniques for synthesizing crucial heterocyclic compounds [35–60]. This study employs an environmentally friendly approach to synthesize novel 1,4‐dihydropyridine‐2,3‐dicarboxylate 4 .…”

A CMC-g-poly(AA-co-AMPS)/Fe3O4 hydrogel nanocomposite as a novel biopolymer-based catalyst in the synthesis of 1,4-dihydropyridines

“…Due to the recent challenges, new protocols for efficiently synthesizing 1,4-DHP derivatives under environmentally safe conditions are still demanded. In continuation of our previous works on the synthesis and application of nanocatalysts in heterocyclic synthesis, 35–43 herein we wish to report the design, synthesis, and use of biopolymer-based CMC- g -poly(AA- co -AMPS)/Fe 3 O 4 hydrogel nanocomposites in the Hantzsch synthesis of 1,4-DHP derivatives under both thermal and ultrasound-assisted conditions (Scheme 1).…”