Synthesis and evaluation of the antibacterial effect of titanium dioxide nanoparticles in comparison with ampicillin, colistin, and ertapenem on Staphylococcus aureus

Bahmani, Mahmoud; Taherikalani, Morovat; Khaksarian, Mojtaba; Rafieian-Kopaei, Mahmoud; Ashrafi, Behnam; Nazer, Mohammadreza; Soroush, Setareh; Abbasi, Naser; Heydari, Rouhollah; Zarei, Leila; Alizadeh, Mohammad

doi:10.4103/jpnr.jpnr_21_18

Cited by 11 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The morphology of the TiO 2 NPs can be tuned by calcination temperature [ 44 ]. In line with previous reports [ 45 – 47 ], we successfully synthesized TiO 2 with two different calcination temperatures, 500 °C confirming the creation of TiO 2 in the anatase form and 900 °C to generate TiO 2 in the rutile form. The success of TiO 2 /GER modification was confirmed by the XRD results showing the impact of homogenization on the crystalline structure of the combination [ 48 , 49 ].…”

Section: Discussionsupporting

confidence: 90%

Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity

Younis,

Milosavljevic,

Fialova

et al. 2023

BMC Microbiol

View full text Add to dashboard Cite

Background The emergence of antibiotic resistance in pathogenic bacteria has become a global threat, encouraging the adoption of efficient and effective alternatives to conventional antibiotics and promoting their use as replacements. Titanium dioxide nanoparticles (TiO2 NPs) have been reported to exhibit antibacterial properties. In this study, we synthesized and characterized TiO2 NPs in anatase and rutile forms with surface modification by geraniol (GER). Results The crystallinity and morphology of modified TiO2 NPs were analyzed by UV/Vis spectrophotometry, X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) with elemental mapping (EDS). The antimicrobial activity of TiO2 NPs with geraniol was assessed against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia coli. The minimum inhibitory concentration (MIC) values of modified NPs ranged from 0.25 to 1.0 mg/ml against all bacterial strains, and the live dead assay and fractional inhibitory concentration (FIC) supported the antibacterial properties of TiO2 NPs with GER. Moreover, TiO2 NPs with GER also showed a significant decrease in the biofilm thickness of MRSA. Conclusions Our results suggest that TiO2 NPs with GER offer a promising alternative to antibiotics, particularly for controlling antibiotic-resistant strains. The surface modification of TiO2 NPs by geraniol resulted in enhanced antibacterial properties against multiple bacterial strains, including antibiotic-resistant MRSA. The potential applications of modified TiO2 NPs in the biomedical and environmental fields warrant further investigation.

show abstract

Section: Discussionsupporting

confidence: 90%

Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity

Younis,

Milosavljevic,

Fialova

et al. 2023

BMC Microbiol

View full text Add to dashboard Cite

show abstract

“…Referring to the results recorded by Rezaee and Kermanshahi(Koseki et al, 2008), TiO 2 /carbopol nanogel with a size of 21 nm and 1% concentration have minimum inhibitory concentrations (MIC) and minimum bactericidal concentration of 0.5%.In addition, the results reported by kumar et al (2017), con rmed that the MIC of TiO 2 /carbopol nanogel at nano size 33 nm was found to be 30 µg/mL against S. aureus and 40 µg/mL against E. coli. These results assured the relation between NP size and antimicrobial effect(Bahmani et al, 2019). Our characterization results of the prepared titanium dioxide nanogel agreed with the previously reported results, which demonstrated that the size of the prepared sample in our study was 51 nm with zeta potential − 28 mV.The attachment ability of the NP to sulfhydryl (R-SH), carboxylic(-COOH), and phosphate (PO 4 ) 3− groups, which cause their conformational change affects the enzymes and proteins of the respiratory cycle, making the cycle ine cient(Mocan et al, 2014) Bahmani et al (2019).…”

supporting

confidence: 71%

“…These results assured the relation between NP size and antimicrobial effect(Bahmani et al, 2019). Our characterization results of the prepared titanium dioxide nanogel agreed with the previously reported results, which demonstrated that the size of the prepared sample in our study was 51 nm with zeta potential − 28 mV.The attachment ability of the NP to sulfhydryl (R-SH), carboxylic(-COOH), and phosphate (PO 4 ) 3− groups, which cause their conformational change affects the enzymes and proteins of the respiratory cycle, making the cycle ine cient(Mocan et al, 2014) Bahmani et al (2019). reported that the antimicrobial activity of TiO 2 was attributed to the effect of NPs on proteins, DNA, and enzymes that are critical for cell proliferation.…”

supporting

confidence: 71%

“…S. aureus, one of the major microorganisms responsible for nosocomial infections, leads to disease through the production of toxins or direct invasion, the formation of abscesses and tissue destruction (including skin infections, endocarditis, pneumonia, empyema, osteomyelitis, and septic arthritis destruction of the tissue). Food poisoning, aphthous ulcers, folliculitis, and furuncles are among other diseases caused by S. aureus (Bahmani et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, characterization, and investigation of pharmacological studies of Some nanoparticles

Youssef,

Ismail,

ElHalim

et al. 2023

Preprint

View full text Add to dashboard Cite

In this paper, a rapid, facile, and cheap method is used to synthesize gold and titanium dioxide nanogel. Cytotoxicity, invitro anti-inflammatory and antioxidant activities were performed. Invitro antimicrobial activities with molecular docking confirmation were carried out. Also, wound healing was performed in rabbit model with H & E illustration. Characterization and identification of the prepared compounds were investigated using X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), and atomic force microscope (AFM). XRD illustrated the presence of the characteristic peaks of the gold and rutile. DLS revealed the homogeneity in size for both gold and rutile nanogel. Where the size of gold/carbopol nanogel and titanium dioxide/carbopol nanogel were 32 nm and 51 nm, respectively, with a zeta-potential of +22 and -28 mV, respectively. BET surface area was found to be 43 and 34 m2/g for gold/carbopol nanogel and titanium dioxide/carbopol nanogel, respectively. The data collected from TEM, SEM, and AFM images studies illustrated the spherical to subspherical shape of gold//carbopol nanogel and titanium dioxide/carbopol nanogel. Cytotoxicity of titanium dioxide/carbopol nanogel and gold/carbopol nanogel on normal human diploid cell line (WI-38 cell) depending on (MTT protocol) and IC50 values were found to be 302.96 and 382.99 ug/ml for titanium dioxide/carbopol nanogel and gold/carbopol nanogel, respectively. Molecular docking with Microbial Beta-Ketoacyl-ACP Synthase II complexed with Malonyl-COA was also presented. The docking score of gold/carbopol nanogel was -3.20 (kcal/mol), however, titanium dioxide/carbopol nanogel was -2.78 (kcal/mol). The anti-microbial effect against ATCC 6538 and ATCC 10221 microorganisms was described and evaluated for the prepared NPs. The MIC50 values recorded were 5 µg/mL and 20 µg/mL for gold/carbopol nanogel and titanium dioxide/carbopol nanogel, respectively. These results confirmed the superior potential antimicrobial effect of gold/carbopol nanogel than titanium dioxide/carbopol nanogel. The antioxidant activity was studied by the DPPH method. The obtained results showed that both synthesized compounds have a potent ability to scavenge hydrogen peroxide when compared to traditional vitamin C. Results of invitro anti-inflammatory activity revealed the potential and superior effect of gold/carbopol nanogel than titanium dioxide/carbopol nanogel. Results of wound healing study revealed the potential and superior efficacy of gold/carbopol nanogel than titanium dioxide/carbopol nanogel.

show abstract

“…In contrast, Charkhian et al found while studying the antibacterial effects of Ag, CuO, NiO, and TiO 2 NPs against Proteus vulgaris that NiO and TiO 2 NPs weakly inhibited bacterial growth in liquid culture (Charkhian et al, 2020). Bahmani et al (2019) studied the effect of TiO 2 NPs compared with those of ampicillin, colistin, and ertapenem on Staphylococcus aureus . Based on the results, the groups with the most significant effect on S. aureus were antibiotics such as ampicillin and ertapenem, while the TiO 2 NPs came second.…”

Section: Antimicrobial Activity Of Tio2 Nanomaterialsmentioning

confidence: 99%

Titanium dioxide nanoparticles: Recent progress in antimicrobial applications

Younis

Haddad

Kosaristanova

et al. 2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

For decades, the antimicrobial applications of nanoparticles (NPs) have attracted the attention of scientists as a strategy for controlling the ever‐increasing threat of multidrug‐resistant microorganisms. The photo‐induced antimicrobial properties of titanium dioxide (TiO2) NPs by ultraviolet (UV) light are well known. This review elaborates on the modern methods and antimicrobial mechanisms of TiO2 NPs and their modifications to better understand and utilize their potential in various biomedical applications. Additional compounds can be grafted onto TiO2 nanomaterial, leading to hybrid metallic or non‐metallic materials. To improve the antimicrobial properties, many approaches involving TiO2 have been tested. The results of selected studies from the past few years covering the most recent trends in this field are discussed in this review. There is extensive evidence to show that TiO2 NPs can exhibit certain antimicrobial features with disputable roles of UV light. Hence, they are effective in treating bacterial infections, although the majority of these conclusions came from in vitro studies and in the presence of some additional nanomaterials. The methods of evaluation varied depending on the nature of the research while researchers incorporated different techniques, including determining the minimum inhibitory concentration, cell count, and using disk and well diffusion methods, with a noticeable indication that cell count was the most and dominant criterion used to evaluate the antimicrobial activity. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

show abstract

Synthesis and evaluation of the antibacterial effect of titanium dioxide nanoparticles in comparison with ampicillin, colistin, and ertapenem on Staphylococcus aureus

Cited by 11 publications

References 3 publications

Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity

Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity

Synthesis, characterization, and investigation of pharmacological studies of Some nanoparticles

Titanium dioxide nanoparticles: Recent progress in antimicrobial applications

Contact Info

Product

Resources

About