Synthesis and Evaluation of Symmetrical and Unsymmetrical Diacyl Ureas, Acyl Urea/Carbamate/Thiocarbamate Derivatives and their Evaluation for FAAH inhibition
Abstract:Fatty acid amide hydrolase (FAAH) is a serine hydrolase enzyme that metabolizes various lipophilic transmitters, including oleamide, anandamide, and 2‐arachidonyl glycerol. These neurotransmitters are part of the endocannabinoid system (ECS) that comprises a neuromodulatory network involved in regulation of various physiological functions, including appetite, pain, reward, motor control, memory, and mood. Previous studies have shown that enhancing the ECS offers a potential therapeutic target for various psych… Show more
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