Synthesis and evaluation of sulfonyl-substituted ruthenium complex as potential antibacterial activity againstStaphylococcus aureus

Abstract

Anti-Staphylococcus aureus infection has become an increasingly common problem, especially the emergence of some multi-drug resistant S. aureus makes bacterial infections difficult to cure. The purpose of this subject is...

Ruthenium terpyridine complexes based on dppz ligands as photodynamic antimicrobial agents against Staphylococcus aureus

“…As previously reported, complexes containing methyl or tert -butyl groups may exhibit enhanced antimicrobial activity against S. aureus . 39–46 Surprisingly, the MIC values under dark and light conditions did not show substantial variation, and it is speculated that the low dose of ruthenium complexes may not be sufficient to entirely inhibit the growth of bacteria and the inherent dark toxicity of this series of complexes against S. aureus . It can be observed that the MBC values of Ru1–Ru8 show significant changes before and after optical exposure, indicating that ruthenium complexes have photo-inactivation effects on S. aureus under blue light irradiation.…”

Evaluation of multi-target iridium(iii)-based metallodrugs in combating antimicrobial resistance and infections caused by Staphylococcus aureus

“…For example, some ruthenium complexes can efficiently kill pathogens by generating ROS. 28 Here, in order to verify whether Ir3 also can induce ROS generation in S. aureus , we monitored the intracellular ROS levels using DCFH-DA, a green fluorescent probe which specifically recognizes ROS in vivo . As shown in Fig.…”

“…As an alternative approach, in order to mitigate antibiotic resistance development, the use of antimicrobial adjuvants to increase antibiotic potency and reverse drug resistance has received much attention in recent years. 33 Next, a checkerboard assay was performed, 28 aiming to investigate whether Ir3 can enhance the potency of the clinically used antibiotic. Here, we selected five different classes of antibiotics, including aminoglycoside antibiotic (gentamicin), macrolide antibiotics (tetracycline), polypeptide antibiotics (polymyxin B), glycopeptide antibiotics (vancomycin) and cephalosporins antibiotics (cefalexin).…”

Synthesis and anti-infective potency study of a Ru-based complex bearing benzonitrile against Staphylococcus aureus

“…Importantly, RuBZ also exhibits a lower MIC value than that of most traditional antibiotics (Fig. 1(A)) and most of the Ru-based complexes we prepared previously, [29][30][31][32][33][34] showing its potential for entering clinical trials. Next, the bacterial growth curves were plotted in the presence of RuBZ, aiming to further confirm its antibacterial effect.…”