2008
DOI: 10.1007/s00044-008-9097-0
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Synthesis and evaluation of some pyrimidine analogs against toxoplasmosis

Abstract: Toxoplasmosis is a worldwide infection caused by the obligate intracellular protozoan parasite Toxoplasma gondii. Some pyrimidine analogs were synthesized to be evaluated for their antitoxoplasma effects in animal experiments. Results were assessed by studying parasite density, estimation of serum Toxoplasma antigen, studying the ultrastructural changes of the parasite, and the histopathological changes of the affected organs and inhibitory activity for dihydrofolate reductase (DHFR) isolated from Cryptosporid… Show more

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Cited by 14 publications
(14 citation statements)
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“…Refluxing compounds 8a-d with triethylorthoformate in acetic anhydride at reflux afforded the corresponding ethyl-N- The structures of products are characterized by 1 H NMR along with 13 C NMR are in agreement with the proposed structures.…”
Section: Synthesissupporting
confidence: 68%
See 2 more Smart Citations
“…Refluxing compounds 8a-d with triethylorthoformate in acetic anhydride at reflux afforded the corresponding ethyl-N- The structures of products are characterized by 1 H NMR along with 13 C NMR are in agreement with the proposed structures.…”
Section: Synthesissupporting
confidence: 68%
“…1 H NMR (300 MHz) and 13 C NMR (75 MHz) spectra were recorded in deuterated CDCl3 and DMSO-d6 on a Bruker AC-300 using non-deuterated solvents as internal reference. All chemical shifts were reported as δ values (ppm) and coupling constants (J) were expressed in Hz.…”
Section: Instrumentationmentioning
confidence: 99%
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“…1 H (400 MHz) and 13 C (100 MHz) NMR spectra were recorded on a Bruker AVANCE II spectrometer in CDCl 3 . Chemical shifts are expressed in δ ppm downfield from TMS as an internal standard.…”
Section: Methodsmentioning
confidence: 99%
“…Particularly pyridine nucleus which is the important constructive part of many natural products and used as antimalarial [2], antitoxoplasma [3], fungicidal [4], antibacterial [5], anti-inflammatory and antitumor agent [6]. The Biginelli reaction [7] has been reported for the synthesis of many pyrimidine darivatives by the one-pot condensation of active methylene, urea and aldehydes.…”
Section: Introductionmentioning
confidence: 99%