Synthesis and Evaluation of Schiff’s Base Indole Derivatives Against Inflammation Induced by Carrageenan in Rats

Abstract

Inflammation is a complex physiological response that can lead to various health issues. The development of effective anti-inflammatory agents is crucial for managing inflammatory conditions. This study focused on synthesizing and evaluating Schiff's base Indole derivatives for their anti-inflammatory potential. Among several synthesized compounds, C1IN, C2IN, C3IN, C7IN, C8IN, and C11IN demonstrated substantial reductions in paw edema and levels of cytokines of inflammation such as IL-1β and TNF-α. In-silico analysis and molecular docking studies further supported the observed effects, indicating potential interactions with TNF-α. The study highlights the therapeutic potential of Schiff's base Indole derivatives in mitigating inflammatory responses. Hence, Schiff's base Indole derivatives present a novel avenue for future research and the potential development of anti-inflammatory drugs.