Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents

Abstract

A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators

“…The synthesis of the target compounds is summarized in Scheme 1 . To synthesize compounds 3a – l and 4a – l , several 2-aminopyrrole-3-carbonitriles 1a – f were prepared by condensing malononitrile with the two intermediates I or II , respectively, in strong basic medium [ 38 , 39 , 40 , 41 ]. The 2-arylidene malononitriles 2a , b were prepared by condensation of malononitrile with the aromatic aldehydes benzaldhyde or anisaldehyde [ 42 , 43 , 44 ].…”

Conformational, Vibrational Spectroscopic and Quantum Chemical Studies on 5-formyl-1h-pyrrole-2-carboxylic acid: A DFT Approach

“…The Fock matrix analysis with the stabilization energy E (2) greater than 2 Kcal mol -1 was shown in Table 2. The larger stabilization intramolecular interaction was observed between LP(N1) to π*(C2-C3) and π*(C4-C5) orbitals with stabilization energy of 39.84 Kcal mol -1 .…”

“…Pyrrole derivatives have potent biological activities such as antimicrobial, antiviral, anti-inflammatory and antitumor agents [1,2]. The different applications of the pyrrole compounds have attracted to study the spectroscopic and vibrational studies of its derivatives.…”

Synthesis and Structure Activity Relationship of Some Indole Derivatives as Potential Anti-inflammatory Agents

“…Due to the importance of this ring system, 39 we prepared some fused o-aminocyano tetrahydrobenzo[b]pyrrole derivatives as an essential propagation step in our search for new pyrrole and pyrrolopyrimidine derivatives, [40][41][42][43] and evaluated them for the anti-inflammatory activities. In addition, a molecular docking study has been done to explain the activity of the biologically active compounds.…”