Synthesis and evaluation of novel almazole D analogs as anticancer agents

Oluyori, Abimbola Peter; Harini, Tirunagari; Sangu, Komal G.; Krishna, E. Vamshi; Jadav, Surender Singh; Misra, Sunil; Rode, Haridas B.

doi:10.1002/ardp.202200102

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Archiv der Pharmazie

2022

DOI: 10.1002/ardp.202200102

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Synthesis and evaluation of novel almazole D analogs as anticancer agents

Abimbola Peter Oluyori

Tirunagari Harini

Komal G. Sangu

et al.

Abstract: Novel almazole D-amide conjugates, esters, and N-alkylated analogs were synthesized and investigated for their anticancer activity against seven cancer cell lines. Among the series, compounds 5g and 5m showed significant anticancer activities against multiple cell lines with moderate selectivity indices. Compound 5g

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2024

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Natural and synthetic 5‐(3′‐indolyl)oxazoles: Biological activity, chemical synthesis and advanced molecules

Liu,

Jiang,

Sukhbaatar

et al. 2024

Medicinal Research Reviews

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Abstract5‐(3′‐Indolyl)oxazole moiety is a privileged heterocyclic scaffold, embedded in many biologically interesting natural products and potential therapeutic agents. Compounds containing this scaffold, whether from natural sources or synthesized, have demonstrated a wide array of biological activities. This has piqued the interest of synthetic chemists, leading to a large number of reported synthetic approaches to 5‐(3′‐indolyl)oxazole scaffold in recent years. In this review, we comprehensively overviewed the different biological activities and chemical synthetic methods for the 5‐(3′‐indolyl)oxazole scaffold reported in the literatures from 1963 to 2024. The focus of this study is to highlight the significance of 5‐(3′‐indolyl)oxazole derivatives as the lead compounds for the lead discovery of anticancer, pesticidal, antimicrobial, antiviral, antioxidant and anti‐inflammatory agents, to summarize the synthetic methods for the 5‐(3′‐indolyl)oxazole scaffold. In addition, the reported mechanism of action of 5‐(3′‐indolyl)oxazoles and advanced molecules studied in animal models are also reviewed. Furthermore, this review offers perspectives on how 5‐(3′‐indolyl)oxazole scaffold as a privileged structure might be exploited in the future.

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Natural and synthetic 5‐(3′‐indolyl)oxazoles: Biological activity, chemical synthesis and advanced molecules

Liu,

Jiang,

Sukhbaatar

et al. 2024

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

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Synthesis and evaluation of novel almazole D analogs as anticancer agents

Cited by 1 publication

References 23 publications

Natural and synthetic 5‐(3′‐indolyl)oxazoles: Biological activity, chemical synthesis and advanced molecules

Natural and synthetic 5‐(3′‐indolyl)oxazoles: Biological activity, chemical synthesis and advanced molecules

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