Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents

Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents

“…The incorporation of sulfur atom in 1,4-naphthoquinone derivatives has led to antifungal, antibacterial, antiviral, and anticancer activities. [8][9][10][11][12] The interesting biological profile resulting due to the presence of a sulfur atom in 1,4-naphthoquinones prompted us to synthesize 1,4-naphthoquinone derivatives 2-24 possessing a sulfur atom in the side chain or inside the ring.…”

Reactions of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with 1,4-naphthoquinone derivatives and the properties of the obtained products

“…Naphthoquinones and their various derivatives as a class display many types of biological activity. They are active against different strains of bacteria and fungi [1][2][3][4][5][6][7][8][9][10], show insecticidal [11,12], molluscicidal [13], and antiproliferative [4,14] properties, and are anticancer agents [15][16][17][18][19][20]. Furthermore, hydrazones have been demonstrated to possess many types of biological activity [21].…”

Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents

“…[2][3][4][5][6][7][8][9][10][11] The biological activity imparted by 1,4-naphthoquinones in most cases relies upon their ability to accept one and/or two electrons to form radical anion or dianion species. 12 The presence of electron-donating or -attracting substituents in 1,4-naphthoquinones modulates the generation of radical anion and the redox property which is further responsible for compounds to catalytically cycle and generate oxidative radicals, such as hydrogen peroxide and superoxide which damage the cells.…”