Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents

Novel indolyl-chalcones target stathmin to induce cancer cell death

“…In total, we synthesized and tested 23 CIT compounds that are structurally distinct from known chalcones with anticancer and anti-inflammatory activities. 5,[25][26][27][28] The discussions of structure-activity relationship (SAR) as well as the identifications of lead compounds, including CIT-026, will be reported separately.…”

Some new indole–coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies

“…Amidst them, heterocycles with polycyclic ring system possess distinct rigid geometry displaying high functional specialization by orienting its substituents in three dimensional spaces, there by attracting great interest [2]. Indole is a bicyclic heterocyclic scaffold that find applications in medical therapy due to a variety of valuable biologic activities such as antiviral [3,4], antiinflammatory [5,6], anti-hyperlipidemic, antihypoglycemic, anti-hypertensive, anti-asthmatic, anti HIV [7], antidepressant [8] and notably anticancer [9][10][11][12][13][14][15] activity. Few marketed anticancer indole derivatives are vincristine, vinblastine, vinorelbine, vindesine, mitraphylline, cediranib and apaziquone [2].…”

Design, synthesis and pharmacophoric model building of new 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamides with potential antiproliferative activity

“…Indoles are constantly of interest for the development of newer biologically active moieties because it is built into proteins in the form of amino acid tryptophan and because of its wide range of pharmacological activities like anti‐inflammatory, antimicrobial, antihistaminic and especially anticancer activity . As indole derivatives have shown good activity as anticancer agents, many structural changes have been made to enhance their anticancer activity .…”