Synthesis and Evaluation of New 2-(Substituted Phenyl)- 3-[5'-(2'-Oxo-2H-chromen-3'-yl)-1,3,4-Oxadiazol-2-yl]-1, 3-Thiazolidin-4-Ones as Anticonvulsants

Abstract

A series of 2-(substituted phenyl)-3-[5'-(2''-oxo-2H-chromen-3'-yl)-1,3,4-oxadiazol-2-yl]-1,3-thiazolidin-4-ones 4-16 were synthesized in good yield and evaluated for their possible anticonvulsant and neurotoxic study. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES test. All the compounds were less neurotoxic than the standard drug phenytoin.