Synthesis and Evaluation of Mesoporous Carbon/Lipid Bilayer Nanocomposites for Improved Oral Delivery of the Poorly Water-Soluble Drug, Nimodipine

Abstract

The data reported herein suggest that the MCLN matrix is a promising carrier for controlling the drug release rate and improving the oral absorption of poorly water-soluble drugs.

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

“…Meanwhile, PTT combined with chemotherapy to achieve synergistic treatment manner, [11][12][13] which not only enhances the cell's uptake of the drug, but also controls the triggering of the release of drug molecules from drug carriers. A variety of NIR photo-absorbing agents have received a new discovery in the PTT including two-dimensional transition metal sulfide (MoS 2 and WS 2 ), [14] nonstoichiometric metal chalcogenides (WOx, Cu 2-x Se, Cu 2-x S), [15][16][17][18] noble metal (Au, Pt) nanomaterials, [19][20][21] carbon-based nanomaterials, [22][23][24][25][26] conducting polymers, [27] and so on. Nowadays, the discoveries of localized surface plasmon resonance (LSPR) nanomaterials have gradually attracted the attention of the scientific community.…”

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

“…It should be noticed that, PEIs@TA-CMS possessed better dissolution-promoting effect then MCM41. It was generally accepted that, drug release from mesoporous silica matrix could be regarded as a diffusion-controlled process mainly dominated by the pore size and pore structure (Zhang et al., 2015 ). However, in this case, MCM41 with the larger pore size released much smaller than PEIs@TA-CMS with smaller pore size (2.8 nm), which was exactly the opposite of the previous studies (Perez et al., 2017 ).…”

Formation of a Supported Lipid Bilayer on Faceted LiYF4:Tm3+/Yb3+ Upconversion Nanoparticles

“…Approaches to creating supported lipid bilayer (SLB) coatings to nanoparticles usually follow a type‐add approach, using the organic film as the inner leaflet. SLB coatings have been successfully added to silica, calcium phosphate, metallic (Au and Ag), quantum/carbon dots, and magnetic (Fe 2 O 3 ) particles . Often these coatings comprise interdigitated leaflets (also referred to in the literature as micellar complexes and pseudo “monolayers”) with film thicknesses of 2–3 nm.…”