Synthesis and evaluation of imidazo[1,2-a]quinoxaline derivatives as potential antifungal agents against phytopathogenic fungi

Ma, Taigui; Zhong, Xu; Yang, Ya; Liu, Wenjing; Guo, Bing; Fan, Judi; Tang, Lei; Fan, Lingling; Li, Yong

doi:10.1007/s11030-023-10739-y

Cited by 1 publication

(2 citation statements)

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“…Effects of compound 5 b on the spore germination [22] Considering the inhibition of spore germination and germ tube elongation is an important means to control fungi diseases, light microscopy was used to study the effects of compound 5 b on the spore germination and germ tube growth of V. mali at three different concentrations (Figure 3). The data of this experiment indicated that compound 5 b could markedly suppress the spore germination in a dose-dependent manner compared with the blank control group, and the inhibition rates at concentrations of 2.5, 5.0, 10.0 μg/mL are 53.7 %, 80.5 %, 100 %, respectively, which was comparable to the positive control chlorothalonil.…”

Section: In Vitro Antifungal Activitymentioning

confidence: 99%

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Design and Synthesis of Novel Phthalide Derivatives containing 1,3,4‐Oxadiazole/1,2,4‐Triazole Units as Potential Antifungal Agents

Li,

Luo,

Liu

et al. 2024

Chemistry & Biodiversity

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Four series of novel 1,3,4‐oxadiazole/1,2,4‐triazole hybrids of phthalide derivatives were designed and synthesized to search for novel potential antifungal agents. Preliminary antifungal activity assay results showed that compounds 4a, 4b, 4m, 5b, 5f, 5h, and 7h exhibited moderate to excellent inhibitory activity against some phytopathogenic fungi. Among them, compound 5b displayed the most outstanding antifungal effects against V. mali and S. sclerotiorum, with the EC50 mean of 3.96 μg/mL and 5.60 μg/mL, respectively, which was superior to those of commercial fungicides hymexazol and chlorothalonil. Furthermore, compound 5b could completely suppress the spore germination of V. mali at a concentration of 10 μg/mL. Finally, molecular docking revealed that the potential target for the antifungal activity of compound 5b was succinate dehydrogenase (SDH). This research provides novel candidate compounds for the prevention of phytopathogenic fungi.

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Section: In Vitro Antifungal Activitymentioning

confidence: 99%

“…The antifungal activity and spore germination of the compounds were evaluated according to the standard operating methods reported in our previous work. [5,22] (Supporting Information)…”

Section: Biological Activitymentioning

confidence: 99%