Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems

Ueki, Akiharu; Un, Keita; Mino, Yuka; Yoshida, Mitsuru; Kawakami, Shigeru; Ando, Hiromune; Ishida, Hideyuki; Yamashita, Fumiyoshi; Hashida, Mitsuru; Kiso, Makoto

doi:10.1016/j.carres.2014.06.028

Cited by 12 publications

(7 citation statements)

References 40 publications

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“…Among them, galactose displayed ah ighera ffinity for ASGPR. [29] Glycosylated conjugates were specifically taken up into various liver cells including hepatocytes,m acrophages,a nd Kupffer cells, which were proportionally associated with the amountso fA SGPR, mannose-, and fucose-binding receptors. [30,31] The targeting properties of carbohydrates is commonly applied to surface modificationso fp harmaceutical vectors to improve their targeting capacity towardt he liver.L iposomes functionalized with mono-o rd isaccharides are used as vehicles for targeting liver cells.…”

Section: Livermentioning

confidence: 98%

“…Several monosaccharides (galactose, N ‐acetylgalactosamine, mannose, lactose, and sialic acid) have been reported to interact with ASGPR, to various extents. Among them, galactose displayed a higher affinity for ASGPR . Glycosylated conjugates were specifically taken up into various liver cells including hepatocytes, macrophages, and Kupffer cells, which were proportionally associated with the amounts of ASGPR, mannose‐, and fucose‐binding receptors …”

Section: Targeting Properties Of Mono‐ and Disaccharidesmentioning

confidence: 99%

“…It is worth noting that galactose-bound taxoids 28 and 32 had advantages over glucose-bound (27, 31)a nd mannose-bound (29, 33)t axoidsi nt he inhibition of tumor growth. Moreover, mannose-bound taxoids 29 and 33 decomposedm uch more slowly than galactose-and glucose-bound taxoids ( 27,28,31,32), accompaniedw ith ac onsiderable amount of glycosylated taxoids (27)(28)(29)(30)(31)(32)(33)(34)e xcreted in the body prior to degradation. [68] In the modification of cisplatin and oxaliplatin using monosaccharides,g alactosylated and mannosylated conjugates displayedh ighere fficacy against cancer cells and lower toxic effects toward normalc ells than the glucosylated and rhamnosy- Figure 7.…”

Section: Sugar Typementioning

confidence: 99%

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Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

Yuan

Chen

et al. 2018

ChemMedChem

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Carbohydrates and their conjugates play important roles in many biological processes including fertilization, differentiation, development, immune response, and infection. Their activities are largely dependent on the properties of terminal mono- or disaccharides. Galactose, mannose, fucose, glucose, sialic acid, etc., are commonly used as powerful scaffolds installed on drug molecules for targeting specific tissues including brain, liver, and cancers, and as epitopes for enhancing the targeting of various vaccines. This review focuses on the influence of their structural variations, including changes in sugar type, substituent groups and their positions, as well as length of linker portion, on the targeting of drugs or their efficacy. Particular attention is paid to the targeting properties of mono- and disaccharides applied in drug design and discovery.

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Section: Livermentioning

confidence: 98%

Section: Targeting Properties Of Mono‐ and Disaccharidesmentioning

confidence: 99%

Section: Sugar Typementioning

confidence: 99%

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Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

Yuan

Chen

et al. 2018

ChemMedChem

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“…Some researchers worked on improvement of mechanical properties of chitosan with the help of inorganic nanofillers . Many researchers explored newer carrier systems such as metal and metal oxide nanoparticles, polymeric micelles, liposome's, dendrimers, and carbon nanotube, as targeting or controlling agents for expected drug release profile. Required characteristics of the carrier are binding sites for drug, biocompatibility, nontoxic nature, site specificity, safer elimination, and improved drug solubility .…”

Section: Introductionmentioning

confidence: 99%

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

et al. 2019

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This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “n” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism.

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“…However, increasing amounts of 1 in liposomal formulations cause some problems such as reduced specificity of uptake due to the positive charge of the amidine moiety. Recently, Ueki et al . reported the synthesis of the neutral mannose‐cholesterol conjugates ( 2‐3 ) along with several congeners with alternative monosaccharides in order to address this issue.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Mannose‐Cholesterol Conjugates for Targeted Liposomal Drug Delivery

et al. 2016

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Several novel, mannose‐cholesterol conjugates for use in targeted liposomal drug delivery were synthesized via a modular strategy utilizing the Cu(I)‐catalysed Huisgen azide‐alkyne cycloaddition (“Click”) reaction. The conjugates, which were fully characterized, comprised either a single mannose unit or a trivalent mannose cluster joined to cholesterol via bifunctional PEG‐based linkers of different lengths. The neutral conjugates offer advantages over a previously reported cationic conjugate and the modular strategy employed can be readily adapted for the preparation of conjugates with alternative targeting groups.

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Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems

Cited by 12 publications

References 40 publications

Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

Synthesis of Mannose‐Cholesterol Conjugates for Targeted Liposomal Drug Delivery

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