Synthesis and Evaluation of Doxorubicin-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery

Du, Yongle; Xia, Long; Jo, Ami; Davis, Richey M.; Bissel, Philippe; Ehrich, Marion; Kingston, David G. I.

doi:10.1021/acs.bioconjchem.7b00756

Cited by 97 publications

(54 citation statements)

References 37 publications

(71 reference statements)

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“…The release of doxorubicin is the most challenging task in the case of cancer cell biology . The release of doxorubicin has been further checked in presence glutathione as reported . Guest molecules, which enter inside cell by endocytosis mechanism generally moves to lysosome before cytoplasmic distribution.…”

Section: Resultssupporting

confidence: 63%

Citrate Stabilized Au‐FexOy Nanocomposites for Variable Exchange Bias, Catalytic Properties and Reversible Interaction with Doxorubicin

et al. 2019

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Exchange bias effect in Au‐FexOy nanocomposites, prepared with regulated Au:Fe content, has been controlled using the variable iron content and the composition of FexOy. A green synthetic route has been adapted at room temperature in aqueous medium for such Au−Fe oxide nanocomposites. Diversity in FexOy compositions has been achieved through Au(III) reduction by Fe powder to obtain Au‐FexOy nanocomposites in presence of gold nanoparticles as seed and threshold amount of sodium citrate as stabilizing agent. The exchange bias effect in selective Au‐FexOy nanocomposites (5Fe, 6Fe, 7Fe and 9Fe) arises from the ferromagnetic‐antiferromagnetic (FM‐AFM) interaction between Fe3O4 and α‐Fe2O3 present in the samples. A theoretical model is used to explain the variation of the exchange bias, coercivity and magnetization for the different samples at various temperatures. These Au‐FexOy nanocomposites have been compared in terms of their catalytic activities for nitroarene reductions and reversible surface interaction with cancer drug doxorubicin.

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Section: Resultssupporting

confidence: 63%

Citrate Stabilized Au‐FexOy Nanocomposites for Variable Exchange Bias, Catalytic Properties and Reversible Interaction with Doxorubicin

et al. 2019

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“…No histopathology was conducted in Au-DOX-treated mice and no differences were observed from mice treated with saline, while mice treated with a DOX equivalent dose showed significant observable lesions. 56 As depicted in Figure 3, negatively charged Au-NCs@ BSA were attached to a mesoporous silica nanoparticle (MSN)-NH 3+ surface with positively charged simple mixing in a solution with neutral aqueous solutions saturated in cargo molecules. Hence, guest molecules were trapped both within the porous channels of MSN and in the capping layer of Au-NC@BSA.…”

Section: Dox Delivery By Au-npsmentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

165

106

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Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Currently, many nanoparticles (NPs) are under investigation for drug delivery including those for cancer therapy. Targeted nanomaterials bind selectively to cancer cells and greatly affect them with only a minor effect on healthy cells. Gold nanoparticles (Au-NPs), specifically, have been identified as significant candidates for new cancer therapeutic modalities because of their biocompatibility, easy functionalization and fabrication, optical tunable characteristics, and chemophysical stability. In the last decade, there has been significant research on Au-NPs and their biomedical applications. Functionalized Au-NPs represent highly attractive and promising candidates for drug delivery, owing to their unique dimensions, tunable surface functionalities, and controllable drug release. Further, iron oxide NPs due to their "superparamagnetic" properties have been studied and have demonstrated successful employment in numerous applications. In targeted drug delivery systems, drug-loaded iron oxide NPs can accumulate at the tumor site with the aid of an external magnetic field. This can lead to incremental effectiveness in drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order for the application of iron oxide NPs in the human body to be realized, they should be biodegradable and biocompatible to minimize toxicity. This review illustrates recent advances in the field drug and small molecule delivery such as fluorouracil, folic acid, doxorubicin, paclitaxel, and daunorubicin, specifically when using gold and iron oxide NPs as carriers of anticancer therapeutic agents.

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“…Conventional chemotherapy has limitations with a lack of solubility in an aqueous solution, side effects at high-doses, and a short bloodstream circulation half-life [4][5][6]. To overcome these limitations, many approaches using nanoparticles for the drug delivery carrier, such as liposomes [7][8][9], dendrimers [10,11], silicon nanoparticles (SiNPs) [12,13], and gold nanoparticles (AuNPs) [14][15][16][17] have been proposed. Among those nanoparticles, the AuNPs have some advantages as the drug delivery carrier, such as that it is easy to synthesize with controlled size and shape, simple surface chemistry, and high biocompatibility [18,19].…”

Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Anticancer Activity of Doxorubicin-loaded DNA-AuNP Nanocarrier for the Ovarian Cancer Treatment

Lee

Kim

et al. 2020

Cancers

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In this study, we have determined the anticancer activity of doxorubicin (Dox)-loaded DNA/gold nanoparticle (AuNP) nanocarrier (Dox-DNA-AuNP) for the treatment of ovarian cancer. The anticancer effect of Dox-DNA-AuNP was evaluated in vitro using the EZ-Cytox cell viability assay on three human ovarian cancer cell lines, SK-OV-3, HEY A8, and A2780. Dox-DNA-AuNP exhibited outstanding activity with good IC50 values of 4.8, 7.4, and 7.6 nM for SK-OV-3, HEY A8, and A2780, respectively. In vivo evaluation further demonstrated the superior anticancer effects of Dox-DNA-AuNP by inhibiting tumor growth compared to free Dox in an established SK-OV-3 xenograft mice model. Dox-DNA-AuNP showed about a 2.5 times higher tumor growth inhibition rate than free Dox. Furthermore, the immunohistochemical analysis of Ki67 antigen expression showed the lowest number of proliferative cells in the ovarian tumor tissue treated with Dox-DNA-AuNP. These results suggest Dox-DNA-AuNP might be a potential effective agent in ovarian cancer chemotherapy.

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Synthesis and Evaluation of Doxorubicin-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery

Cited by 97 publications

References 37 publications

Citrate Stabilized Au‐FexOy Nanocomposites for Variable Exchange Bias, Catalytic Properties and Reversible Interaction with Doxorubicin

Citrate Stabilized Au‐FexOy Nanocomposites for Variable Exchange Bias, Catalytic Properties and Reversible Interaction with Doxorubicin

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

In Vivo and In Vitro Anticancer Activity of Doxorubicin-loaded DNA-AuNP Nanocarrier for the Ovarian Cancer Treatment

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