Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki–Miyaura Cross-Coupling: Discovery of 7-Methylguanosine-Based Molecular Rotors
Blazej A. Wojtczak,
Marcelina Bednarczyk,
Pawel J. Sikorski
et al.
Abstract:Chemical modifications of the mRNA cap structure can
enhance the
stability, translational properties, and half-life of mRNAs, thereby
altering the therapeutic properties of synthetic mRNA. However, cap
structure modification is challenging because of the instability of
the 5′-5′-triphosphate bridge and N7-methylguanosine.
The Suzuki–Miyaura cross-coupling reaction between boronic
acid and halogen compound is a mild, convenient, and potentially applicable
approach for modifying biomolecules. Herein, we describe… Show more
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