Synthesis and evaluation of cytotoxic activities of some substituted isoxazolone derivatives

The synthesis and antitubercular activity of substituted hydrazone,2-pyrazoline-5-one and 2-isoxazoline-5-one derivatives possessing 1,3,4-thiadiazole moiety

“…The pyrazolinone N-H of 3a-e were determined between 11.46-11.64 ppm (6). The protons of the methyl group attached to the 5-isoxazolone ring and hydrazone NH protons were observed as singlets at 2.13-2.27 ppm and 12.40-12.69 ppm respectively (28). M+1 peaks were obtained in the mass spectra of all novel compounds.…”

“…In our previous papers, we have reported that isoxazolinones (11) possess antifungal activity and 1,3,4-thiadiazoles including compounds, isoxazolinones and hydrazones (7)(8)(9)(26)(27)(28) possess antitubercular and cytotoxic activities. Pyrazolinones (6) which are isosters of isoxazolidinones have also shown antitubercular activity.…”

2,2′-((1,4-Dimethoxy-1,4-dioxobutane-2,3-diylidene)bis(azanylylidene))bis(quinoline-3-carboxylic acid)

“…They may be treated as useful tools in organic synthesis since they are small and easy to functionalize molecules that can be utilized to design novel bioactive compounds. It has been proven that these synthetic products exhibit antibacterial [1][2][3][4][5][6][7][8], antifungal [7][8][9][10][11][12][13][14][15][16], antitubercular [3], anticancer [3,6,17,18], antileucemic [5], antinflammatory [19][20][21], antiviral [22], anticonvulsant [1], antioxidant [2,7], and antiandrogenic [23,24] properties. They may act as inhibitors of p38 MAP kinases [25], protein kinase C [26], and protein-tyrosine phosphatase 1B, which consequently cause antiobesity effect [27,28].…”

Synthesis and evaluation of cytotoxic activities of some 1,4-disubstituted thiosemicarbazides, 2,5-disubstituted-1,3,4-thiadiazoles and 1,2,4-triazole-5-thiones derived from benzilic acid hydrazide

“…2,5-Disubstituted 1,3,4-thiadiazoles, synthesis of which frequently include the reaction of acylthiosemicarbazides with acidic reagents such as concentrated sulfuric acid, possess various biological properties such as anticonvulsant (10), antifungal (11,12), antituberculosis (13)(14)(15), antimicrobial (16,17), anti-inflammatory (18), cytotoxic (19), and antiproliferative (20), antioxidant (21)(22) activities. In addition, 1,2,4-triazole-thiones which possess important pharmacological activities such as anticonvulsant (23), anti-inflammatory (24)(25)(26)(27)(28), antibacterial (29), cytotoxic (30,31), antimicrobial (32), anticancer (33,34), and antiviral (35) have found wide use in medicinal chemistry as common structures.…”