Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives

Potent hepatoprotective effect in CCl4-induced hepatic injury in mice of phloroacetophenone fromMyrcia multiflora

“…To obtain phloroacetophenone, 4,6-dihydroxy-2-O-(β-D-glucopyranosyl) acetophenone (200 mg) was treated with 3 N HCl in methanol (200 ml) at a reflux temperature of 100°C for 30 min (18–20). After neutralization by careful addition of 20% aqueous NaHCO 3 and elimination of methanol under vacuum and controlled temperature, the phloracetophenone was extracted with CH 2 Cl 2 , followed by the evaporation of solvent and recrystallization with boiling water.…”

Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors

“…1-(2,4,6-Trihydroxy-phenyl)-ethanone was treated with chloromethyl methyl ether and potassium carbonate in acetone at room temperature to produce 1-(2-hydroxy-4,6-bis-methoxymeth-oxy-phenyl)-ethanone 1. Intermediates 2a-n were prepared by Claisen-Schmidt condensation of 1 with appropriate aromatic aldehydes, followed by cyclization in refluxing ethanol in the presence of NaOAc, which yielded flavanones 3a-n. Demethoxymethylation of 3a-n was carried out in 5 M HCl in refluxing methanol to yield 4a-n 38,39 . The spectral data obtained from infrared spectroscopy, 1 H-NMR and mass spectrometry were consistent with the structures proposed.…”

Antihyperglycemic activity of naphthylchalcones

“…Chalcones are compounds previously formed in natural synthesis of flavonoids in plants and are known to exhibit several biological activities such as apoptosis induction, an anti-proliferative action in various cancer cell types, inhibition of pro-inflammatory mediators, antiplatelet activity, potential antimalarial activity, among others [1][2][3][4][5][6][7]. It is well known that different substituents at different positions on the core structure of chalcones ( Fig.…”